Rheumatoid arthritis (RA) is a chronic autoimmune disease. Targeting NLRP3
inflammasome, specifically its interaction with NEK7 via the LRR domain of NLRP3, is a …

NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a
cytoplasmic multiprotein complex composed of the innate immune receptor protein NLRP3 …

NLRP3 inflammasome is involved in the pathology of multiple human inflammatory diseases
but there are still no clinically available medications targeting the NLRP3 inflammasome. We …

The NLRP3 inflammasome plays a crucial role in innate immune-mediated inflammation
and contributes to the pathogenesis of multiple autoinflammatory, metabolic and …

Background: Inflammation is the body's immune system's fast coordinating response to
irritants caused by pathogens, external injuries, and chemical or radiation effects. The …

The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of
human diseases. A few compounds have been developed to inhibit NLRP3 inflammasome …

The NLRP3 inflammasome represents a cytoplasmic multiprotein complex with the
capability to recognize a wide range of pathogen-derived, environmental, and endogenous …

Inflammasomes are multiprotein complexes that drive inflammation and contribute to
protective immunity against pathogens and immune pathology in autoinflammatory …

Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …

The NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome has been
linked to the release of pro-inflammatory cytokines and is essential for innate defence …