Background Chagas disease, a condition caused by Trypanosoma cruzi, is an endemic
disease in Latin American countries that affects approximately eight million people …

SUMMARY Introduction: Chagas disease and Leishmaniasis are neglected diseases
caused by the Trypanosoma cruzi and kentoplastid parasites Leishmania spp. Parasitic …

A series of new 2-aminonaphthoquinones and related compounds were synthesized and
evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited …

In continuation our effort to research the chemical space of aryloxy-naphthoquinones as
potential anti-Chagas agents, we synthesized nine derivatives and these compounds were …

Chagas disease, caused by Trypanosoma cruzi, is a widespread infection in Latin America.
Currently, only 2 partially effective and highly toxic drugs, ie, benznidazole and nifurtimox …

Synthetic and natural naphthofuranquinones were tested in vitro against three Trypanosoma
cruzi strains with different drug susceptibility to nifurtimox and benznidazole in vivo. Four …

The discovery and development of essential drugs for Chagas disease is a major concern
worldwide. New substituted 1, 4-naphthoquinones were synthesized and tested against the …

In the search for new therapeutic alternatives for Chagas disease, a series of six aryloxy-
naphthoquinone derivatives were synthesized and evaluated in vitro against Trypanosoma …

Chagas disease, Sleeping sickness and Leishmaniasis, caused by trypanosomatids
Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp., respectively, are considered …

Background Chagas' disease is a condition caused by the protozoan Trypanosoma cruzi
that affects millions of people, mainly in Latin America where it is considered endemic. The …