JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the
myriad of cellular processes initiated by various types of ligands such as growth factors …

Intercellular communication between tumor cells, immune cells and the stroma characterises
the tumor microenvironment, which is instrumental for establishing the ecological niche that …

Background: JAK/STAT signal pathway, a requisite part in the signaling process of growth
factors and cytokines, has become attractive targets for numerous immune, inflammatory …

Various human malignancies are characterized by excessive activation of the Janus family
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …

Aberrant activation of signal transducer and activator of transcription (STAT) proteins is
associated with the development and progression of solid tumors. However, as transcription …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Cytokines are molecules that play critical roles in the regulation of a wide range of normal
functions leading to cellular proliferation, differentiation and survival, as well as in …

Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway is a
common signaling pathway used to transduce signals from the extracellular to the …

Persistent JAK-STAT3 signaling is implicated in many aspects of tumorigenesis. Apart from
its tumor-intrinsic effects, STAT3 also exerts tumor-extrinsic effects, supporting tumor survival …

Inflammation is at the forefront of carcinogenesis, tumor progression and resistance to
therapy. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) …