Colorectal cancer (CRC) arises by a continuous process of genetic diversification and clonal
evolution. Multiple genes and pathways have a role in tumor initiation and progression. The …

During the past years, molecular studies through high-throughput technologies have led to
the confirmation of critical alterations in colorectal cancer (CRC) and the discovery of some …

Intratumoral heterogeneity including genetic and nongenetic mechanisms refers to
biological differences amongst malignant cells originated within the same tumor. Both, cell …

Simple Summary Metastatic colorectal cancer is a complex, prevalent, and life-threatening
disease influenced by various factors that affect its progression, evolution, and treatment …

Improvements in screening and preventive measures have led to an increased detection of
early stage colorectal cancers (CRC) where patients undergo treatment with a curative …

Global statistics have placed colorectal cancer (CRC) as the third most frequently diagnosed
cancer and the fourth principal cause of cancer-related deaths worldwide. Improving survival …

BACKGROUND: Colorectal cancer (CRC) prognosis and survival are strictly related to the
development of distant metastases. New targeted therapies have increased patient survival …

The widespread use of next generation sequencing (NGS) has led to a refined
understanding of the genomics of colorectal cancer (CRC). However, progress in the use of …

Attempts at eradicating metastatic cancers with targeted therapies are limited by the
emergence of resistant subclones bearing heterogeneous (epi) genetic changes. We used …

Despite the great progress in our understanding of the molecular basis of human cancer, the
heterogeneity of individual tumors and the evolutionary pressures imposed by therapy have …