High energy intake and excessive body fatness impair mammogenesis in prepubertal
ruminants. High energy intake and excessive fatness also increase serum leptin. Our …

Leptin is a cytokine-like hormone that functions as a link between obesity and breast cancer
(BC). Leptin treatment induces Epithelial to Mesenchymal Transition (EMT) in BC cell lines …

This study determined if a perturbation in in utero adipogenesis leading to later life adipose
tissue (AT) dysfunction underlies programming of cardiometabolic risk in offspring born to …

Twenty-one-day-old female BALB/c mice were divided into three groups and fed a diet
containing 0, 5, and 20% fat (corn oil). Ten days prior to sacrifice, one-half of the mice were …

Beige adipocytes have become a promising therapeutic target to combat obesity. Our senior
author Dr. B. Xue previously discovered a transient but significant induction of beige …

Events during early life can affect reproductive and metabolic functions in adulthood. We
evaluated the programming effects of a single early postnatal estradiol injection (within 3h …

Maternal obesity is linked with increased adverse pregnancy outcomes for both mother and
child. The metabolic impact of excessive fat within the context of pregnancy is not fully …

Leptin is a potential regulator of conceptus development. We have previously suggested that
in primate pregnancy, leptin biosynthesis is regulated by estrogen in a tissue-specific …

The pubertal mammary gland is an ideal model for experimental morphogenesis. The
primary glandular branching morphogenesis occurs at this time, integrating epithelial cell …

In support of leptin's physiological role as humoral signal of fat mass, we have shown that
adipocyte volume is a predominant determinant of leptin mRNA levels in anatomically …