With the advent of new immunosuppressants and formulations, the elucidation of molecular
targets and the evolution of therapeutic drug monitoring, the field of organ transplantation …

Most of the immunosuppressants used in organ transplantation are characterized by a
narrow therapeutic index, whereby underdosing is associated with increased risk of …

Pharmacogenetics is the discipline that translates information on genetic variability into
prediction of the pharmacokinetics and pharmacodynamics effects of drugs. It was hoped …

One of the main tasks in the management of organ transplantation is the optimization of
immunosuppressive therapy, in order to provide therapeutic efficacy limiting drug-related …

Interindividual variability in immunosuppressive drug responses might be partly explained
by genetic variants in proteins involved in the immune response or associated with IS …

Tailoring of immunosuppressive drug therapy to the specific requirements of the individual
patient to optimize efficacy and minimize toxicity remains one of the biggest challenges in …

The promising role of pharmacogenetics in the attempt to elucidate the inherited basis of
differences between individual responses to drugs lies in its potential ability to identify the …

The immunosuppressive drugs used to prevent the rejection of transplanted organs have a
narrow therapeutic index. Under treatment results in episodes of rejection leading to either …

Transplantation has transformed the treatment of patients with organ failure in a number of
clinical settings, and immunosuppressive drug therapy is fundamental to its success …

The use of immunosuppressive agents in the treatment of transplant rejection and
autoimmune disorders is gaining momentum, with significant improvements of both graft and …