There are an estimated 285 million people with visual impairment worldwide, of whom 39
million are blind. The pathogenesis of many eye diseases remains poorly understood. The …

Purpose: To better understand ocular hypertension–induced early molecular alterations that
may determine the initiation of neurodegeneration in human glaucoma, this study analyzed …

AIM To preliminarily test proteomics in aqueous humor in patients with dry age-related
macular degeneration (AMD) by using the proteomic technology. METHODS Aqueous …

Methods Aqueous humor samples were prospectively collected from 38 eyes (26 primary
open angle glaucoma [POAG] and 12 primary angle closure glaucoma [PACG] eyes) of 37 …

Introduction Primary open angle glaucoma (POAG) is a progressive optic neuropathy
characterized by impaired aqueous outflow and extensive remodeling in the trabecular …

Primary open angle glaucoma (POAG) is a complex disease and a leading cause of
irreversible blindness, and its underlying pathophysiology remains poorly understood …

The pathophysiologic mechanisms leading to the malfunction of the trabecular meshwork
(TM)–Schlemm's canal (SC) outflow pathway in glaucoma are still unclear. We hypothesize …

Primary open‐angle glaucoma (POAG) is characterized by irreversible neurodegeneration
accompanied by visual field defects and high intraocular pressure. Currently, an effective …

Despite improving understanding of glaucoma, key molecular players of neurodegeneration
that can be targeted for treatment of glaucoma, or molecular biomarkers that can be useful …

Current evidence suggests that exposure to chronically induced intraocular pressure (IOP)
leads to neurodegenerative changes in the inner retina. This study aimed to determine …