Proteomics of aqueous humor as a source of disease biomarkers in retinoblastoma

A Galardi, C Stathopoulos, M Colletti… - International Journal of …, 2022 - mdpi.com
Aqueous humor (AH) can be easily and safely used to evaluate disease-specific biomarkers
in ocular disease. The aim of this study was to identify specific proteins biomarkers in the AH …

Complement system proteins in the human aqueous humor and their association with primary open-angle glaucoma

A Vashishtha, SW Maina, J Altman, G Jones… - Journal of Personalized …, 2023 - mdpi.com
This study discovers the complement protein profile in the aqueous humor (AH) of human
subjects and investigates its association with primary open-angle glaucoma (POAG) …

Immunoproteomic analysis of potential serum biomarker candidates in human glaucoma

G Tezel, IL Thornton, MG Tong, C Luo… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: Evidence supporting the immune system involvement in glaucoma includes
increased titers of serum antibodies to retina and optic nerve proteins, although their …

Candidate glaucoma biomarkers: From proteins to metabolites, and the pitfalls to clinical applications

AFV Cueto, L Álvarez, M García, A Álvarez-Barrios… - Biology, 2021 - mdpi.com
Simple Summary Glaucoma is a devastating eye disease causing progressive vision loss
and consequent irreversible blindness. The global prevalence of glaucoma is estimated at …

[HTML][HTML] Molecular biomarkers in glaucoma

SK Bhattacharya, RK Lee, FH Grus - … ophthalmology & visual …, 2013 - jov.arvojournals.org
The seventh annual ARVO/Pfizer Ophthalmic Research Institute conference was held Friday
and Saturday, April 29 and 30, 2011, at the Fort Lauderdale Hyatt Regency Pier 66, Fort …

Proteomic analysis of aqueous humor in patients with pathologic myopia

M Xue, Y Ke, X Ren, L Zhou, J Liu, X Zhang, X Shao… - Journal of …, 2021 - Elsevier
Complications from pathologic myopia (PM) are a major cause of visual impairment and
blindness. However, an efficient clinical therapeutic strategy for PM is still lacking. The aim of …

Proteome alterations in the aqueous humor reflect structural and functional phenotypes in patients with advanced normal-tension glaucoma

SH Lee, JH Jung, TK Park, CE Moon, K Han, J Lee… - Scientific reports, 2022 - nature.com
Previous reports have shown possible association between altered protein levels in
aqueous humor (AH) and normal-tension glaucoma (NTG), but the underlying pathogenetic …

Proteomics reveal Cochlin deposits associated with glaucomatous trabecular meshwork

SK Bhattacharya, EJ Rockwood, SD Smith… - Journal of Biological …, 2005 - ASBMB
The etiology of primary open angle glaucoma, a leading cause of age-related blindness,
remains poorly defined, although elevated intraocular pressure (IOP) contributes to the …

What are the biomarkers for glaucoma?

O Golubnitschaja, J Flammer - Survey of ophthalmology, 2007 - Elsevier
A biomarker is a parameter that can objectively be measured and evaluated as an indicator
of either normal or pathologic processes, or of a response to therapeutic intervention …

Aqueous humor protein concentration in patients with primary open-angle glaucoma under clinical treatment

TS Prata, EV Navajas, LAS Melo Jr… - Arquivos Brasileiros …, 2007 - SciELO Brasil
OBJETIVOS: Comparar a concentração total de proteínas no humor aquoso entre pacientes
com glaucoma primário de ângulo aberto e sem glaucoma. MÉTODOS: Foram coletadas …