The role of autophagy, a lysosomal degradation pathway which prevents cellular damage, in
the maintenance of adult mouse hematopoietic stem cells (HSCs) remains unknown …

Long known as terminal degradation stations, lysosomes have emerged as sophisticated
signalling centres that govern cell growth, division and differentiation. Lysosomes interface …

Adult stem cells provide the basis for regeneration of aging tissue. Their dual ability for self-
renewal and multilineage differentiation is controlled by direct interaction with a specific …

Cellular stress responses serve as crucial decision points balancing persistence or culling of
hematopoietic stem cells (HSCs) for lifelong blood production. Although strong stressors cull …

Lysosomes, with their arsenal of degradative enzymes are increasingly becoming an area of
interest in the field of oncology. The changes induced in this compartment upon …

Recent studies have demonstrated that, in addition to their central role in cellular catabolic
reactions, lysosomes are implicated in many cellular processes, including metabolism …

Lysosomes are acidic cell compartments containing a large set of hydrolytic enzymes. These
lysosomal hydrolases degrade proteins, lipids, polysaccharides, and nucleic acids into their …

Hematopoietic stem cells (HSCs) reside and self-renew in the bone marrow (BM) niche.
Overall, the signaling that regulates stem cell dormancy in the HSC niche remains …

Lysosomal cell death is triggered by lysosomal membrane permeabilization (LMP) and
subsequent release of lysosomal hydrolases from the lysosomal lumen into the cytosol …

Lysosomes (or lytic bodies) were so named because they contain high levels of hydrolytic
enzymes. Lysosome function and dysfunction have been found to play important roles in …