Lysosomal cell death is triggered by lysosomal membrane permeabilization (LMP) and
subsequent release of lysosomal hydrolases from the lysosomal lumen into the cytosol …

Scl and Lyl1 encode two related basic-helix-loop-helix transcription factors implicated in T
cell acute lymphoblastic leukemia. Previous studies showed that Scl is essential for …

THE process of regulated secretion (reviewed in Bugress and Kelly, 1987) is critical for the
correct biological functioning of many different cells of the immune system, most of which are …

Chediak–Higashi syndrome is an autosomal recessive disorder that affects vesicle
morphology. The Chs1/Lyst protein is a member of the BEige And CHediak family of …

Lysosomes are cellular organelles primarily involved in degradation and recycling
processes. During lysosomal exocytosis, a Ca 2+-regulated process, lysosomes are docked …

Lysosomes are sites of active metabolism in a cell. They contain various hydrolases that
degrade extracellular and intracellular materials during endocytosis and autophagy …

Background Dormant leukemia stem cells (LSC) promote therapeutic resistance and
leukemic progression as a result of unbridled activation of stem cell gene expression …