MDMA related neuro-inflammation and adenosine receptors

F Kermanian, M Seghatoleslam… - Neurochemistry …, 2022 - Elsevier
methylenedioxymethamphetamine (MDMA) is a world-wide abused psychostimulant, which
has the neurotoxic effects on dopaminergic and serotonergic neurons in both rodents and …

Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms

R Moratalla, A Khairnar, N Simola, N Granado… - Progress in …, 2017 - Elsevier
Amphetamine-related drugs, such as 3, 4-methylenedioxymethamphetamine (MDMA) and
methamphetamine (METH), are popular recreational psychostimulants. Several preclinical …

The A2a adenosine receptor modulates the reinforcement efficacy and neurotoxicity of MDMA

J Ruiz-Medina, C Ledent, O Carretón… - Journal of …, 2011 - journals.sagepub.com
Adenosine is an endogenous purine nucleoside that plays a neuromodulatory role in the
central nervous system. A2a adenosine receptors have been involved in reward-related …

The role of adenosine A1 and A2A receptors in the caffeine effect on MDMA-induced DA and 5-HT release in the mouse striatum

AM Górska, K Gołembiowska - Neurotoxicity research, 2015 - Springer
Methylenedioxymethamphetamine (MDMA,“ecstasy”) popular as a designer drug is often
used with caffeine to gain a stronger stimulant effect. MDMA induces 5-HT and DA release …

MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase

JH Anneken, JI Cunningham, SA Collins… - Journal of NeuroImmune …, 2013 - Springer
Methylenedioxymethamphetamine (MDMA; Ecstasy) is a popular drug of abuse with well-
documented acute effects on serotonergic, dopaminergic, and cholinergic transmitter …

Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions

A Khairnar, L Frau, A Plumitallo, M Morelli… - Journal of Caffeine …, 2014 - liebertpub.com
Background: Previous studies by our group have demonstrated that caffeine, an antagonist
of adenosine A1 and A2A receptors, amplifies the glial activation induced by 3, 4 …

Effects of adenosine A2a receptor agonist and antagonist on hippocampal nuclear factor-kB expression preceded by MDMA toxicity

F Kermanian, M Soleimani, A Ebrahimzadeh… - Metabolic brain …, 2013 - Springer
There is an abundance of evidence showing that repeated use of 3, 4-
methlylenedioxymethamphetamine (MDMA; ecstasy) is associated with brain dysfunction …

3, 4‐methylenedioxymethamphetamine increases excitability in the dentate gyrus: role of 5 HT 2A receptor‐induced PGE 2 signaling

SA Collins, C Huff, N Chiaia… - Journal of …, 2016 - Wiley Online Library
methylenedioxymethamphetamine (MDMA) is a widely abused psychostimulant, which
causes release of serotonin in various forebrain regions. Recently, we reported that MDMA …

Role of adenosine receptor subtypes in methamphetamine reward and reinforcement

KA Kavanagh, DC Schreiner, SC Levis, CE O'Neill… - …, 2015 - Elsevier
The neurobiology of methamphetamine (MA) remains largely unknown despite its high
abuse liability. The present series of studies explored the role of adenosine receptors on MA …

The role of adenosine receptor agonist and antagonist on Hippocampal MDMA detrimental effects; a structural and behavioral study

F Kermanian, M Mehdizadeh, M Soleimani… - Metabolic brain …, 2012 - Springer
There is abundant evidence showing that repeated use of MDMA (3, 4-
Methylenedioxymethamphetamine, ecstasy) has been associated with depression, anxiety …