In this study, proportional response addition (Prop-RA), a model for predicting response from
chemical mixture exposure, is demonstrated and evaluated by statistically analyzing data on …

The interaction-based hazard index (HIINT), a mixtures approach to characterizing
toxicologic interactions, is demonstrated and evaluated by statistically analyzing data on four …

Mixture risk assessment is often hampered by the lack of dose–response information on the
mixture being assessed, forcing reliance on component formulas such as dose addition. We …

The Environmental Protection Agency (EPA) guidelines for health risk assessment of
chemical mixtures (US EPA, 1986) recommend the calculation of a separate HI for each …

Due to the ever-increasing number of chemicals coming to market, and the cost of
performing traditional in vivo studies, there has been a shift toward the use of less costly …

The most commonly used chemical mixtures risk assessment methods involve simple
notions of additivity and toxicological similarity. Newer methods are emerging in response to …

Mixture risk assessments are most often based on toxicology information for the component
chemicals, primarily because dose-response information on the mixture of concern is …

Mechanistic studies with simple mixtures have provided insights into the nature of
interactions among chemicals that lead to non-additive effects and have elucidated the …

Mixture toxicity assessment is indeed necessary for humans and ecosystems that are
continually exposed to a variety of chemical mixtures. This paper describes an R package …

One of the initial steps in remediating contaminated environments is to assess the human
and ecological health risk associated with exposure to contaminants in a specific medium …