It is intuitive that patients who are seriously ill because of infection will benefit from the
earliest possible administration of antibiotics effective against the causative pathogen …

The recommended fixed timing of antibiotic administration is one of the reasons why the
Infectious Disease Society of America did not endorse the Surviving Sepsis Campaign …

This article is a brief overview of empiric antibiotic selection for sepsis and septic shock. The
article includes a differential diagnosis of the mimics of sepsis and stresses a strategy for …

The randomized controlled trial is the ideal study design to show harm; however, for reasons
that are self-evident, patients cannot be randomized to appropriate vs inappropriate …

Optimal and responsible use of antibiotics : Current Opinion in Critical Care Optimal and
responsible use of antibiotics : Current Opinion in Critical Care Log in or Register Subscribe to …

Introduction: Severe infections in critically ill patients carry a high morbidity and mortality
rate. Given the impact of early and broad-spectrum empirical therapy in several studies and …

Editorials 1932 www. ccmjournal. org August 2014• Volume 42• Number 8 to reduce risk of
initial inappropriate therapy (7). Finally, inappropriate antibiotic dosing, an often neglected …

Sepsis affects approximately 750,000 individuals in the United States each year, accounting
for 2.1% to 4.3% of hospitalizations, and 11% of all admissions to the ICU. 1 From 1979 to …

Abstract Purpose of Review Early antibiotic administration is the cornerstone of sepsis
treatment guidelines and quality measures. We summarize recent key literature on sepsis …

Well-designed observational studies link lower sepsis mortality with earlier antibiotic
initiation, leading advocacy and regulatory bodies to embrace antibiotic initiation time as a …