Broadly neutralizing antibodies developed by an HIV-positive elite neutralizer exact a replication fitness cost on the contemporaneous virus
DN Sather, S Carbonetti, J Kehayia, Z Kraft… - Journal of …, 2012 - Am Soc Microbiol
Approximately 1% of those infected with HIV-1 develop broad and potent serum cross-
neutralizing antibody activities. It is unknown whether or not the development of such …
neutralizing antibody activities. It is unknown whether or not the development of such …
[PDF][PDF] Strain-specific V3 and CD4 binding site autologous HIV-1 neutralizing antibodies select neutralization-resistant viruses
The third variable (V3) loop and the CD4 binding site (CD4bs) of the HIV-1 envelope are
frequently targeted by neutralizing antibodies (nAbs) in infected individuals. In chronic …
frequently targeted by neutralizing antibodies (nAbs) in infected individuals. In chronic …
HIV-1 fitness cost associated with escape from the VRC01 class of CD4 binding site neutralizing antibodies
Broadly neutralizing antibodies (bNAbs) have been isolated from selected HIV-1-infected
individuals and shown to bind to conserved sites on the envelope glycoprotein (Env) …
individuals and shown to bind to conserved sites on the envelope glycoprotein (Env) …
Susceptibility to neutralization by broadly neutralizing antibodies generally correlates with infected cell binding for a panel of clade B HIV reactivated from latent …
Y Ren, M Korom, R Truong, D Chan, SH Huang… - Journal of …, 2018 - Am Soc Microbiol
Efforts to cure human immunodeficiency virus (HIV) infection are obstructed by reservoirs of
latently infected CD4+ T cells that can reestablish viremia. HIV-specific broadly neutralizing …
latently infected CD4+ T cells that can reestablish viremia. HIV-specific broadly neutralizing …
Conformational epitope-specific broadly neutralizing plasma antibodies obtained from an HIV-1 clade C-infected elite neutralizer mediate autologous virus escape …
Broadly neutralizing antibodies isolated from infected patients who are elite neutralizers
have identified targets on HIV-1 envelope (Env) glycoprotein that are vulnerable to antibody …
have identified targets on HIV-1 envelope (Env) glycoprotein that are vulnerable to antibody …
Comprehensive cross-clade characterization of antibody-mediated recognition, complement-mediated lysis, and cell-mediated cytotoxicity of HIV-1 envelope-specific …
S Mujib, J Liu, AKMN Rahman, JA Schwartz… - Journal of …, 2017 - Am Soc Microbiol
Immunotherapy with passive administration of broadly neutralizing HIV-1 envelope-specific
antibodies (bnAbs) in the setting of established infection in vivo has yielded mixed results …
antibodies (bnAbs) in the setting of established infection in vivo has yielded mixed results …
[HTML][HTML] Escape from autologous humoral immunity of HIV-1 is not associated with a decrease in replicative capacity
EM Bunnik, MSD Lobbrecht, AC van Nuenen… - Virology, 2010 - Elsevier
Autologous HIV-1-specific neutralizing antibodies (NAbs) seem unable to inhibit viral
replication as they rapidly select for neutralization escape variants. However, NAbs could …
replication as they rapidly select for neutralization escape variants. However, NAbs could …
[HTML][HTML] Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and …
Identifying the targets of broadly neutralizing antibodies to HIV-1 and understanding how
these antibodies develop remain important goals in the quest to rationally develop an HIV-1 …
these antibodies develop remain important goals in the quest to rationally develop an HIV-1 …
Neutralizing activity of broadly neutralizing anti-HIV-1 antibodies against clade B clinical isolates produced in peripheral blood mononuclear cells
YZ Cohen, JCC Lorenzi, MS Seaman… - Journal of …, 2018 - Am Soc Microbiol
Recently discovered broadly neutralizing antibodies (bNAbs) against HIV-1 demonstrate
extensive breadth and potency against diverse HIV-1 strains and represent a promising …
extensive breadth and potency against diverse HIV-1 strains and represent a promising …
Multiple pathways of escape from HIV broadly cross-neutralizing V2-dependent antibodies
Broadly cross-neutralizing (BCN) antibodies are likely to be critical for an effective HIV
vaccine. However, the ontogeny of such antibodies and their relationship with autologous …
vaccine. However, the ontogeny of such antibodies and their relationship with autologous …