Dysfunctional glucocorticoid receptor (GR) signaling has been shown to be involved in the
pathogenesis of depressive behavior in mice and humans. In accordance with this …

Recently, we have demonstrated that conditional inactivation of glucocorticoid receptors
(GRs) in the noradrenergic system, may evoke depressive-like behavior in female but not …

Stress and the resulting increase in glucocorticoid levels have been implicated in the
pathophysiology of depressive disorders. We investigated the effects of chronic restraint …

Major depression is thought to originate from maladaptation to adverse events, particularly
when impairments occur in mood-related brain regions. Hypothalamus–pituitary–adrenal …

The gene coding for the neurotrophin Brain-Derived Neurotrophic Factor (BDNF) is a stress-
responsive gene. Changes in its expression may underlie some of the pathological effects of …

Prolonged and intense stress chronically increases blood concentration of glucocorticoids,
which in turn causes downregulation of glucocorticoid receptor (GR) in the central nervous …

The neurotrophin and serotonin (5-HT) hypotheses of depression were studied in a mouse
model of reduced glucocorticoid receptor (GR) function (GR+/− mice), which recently has …

Altered glucocorticoid receptor (GR) signaling is a postulated mechanism for the
pathogenesis of major depression. To mimic the human situation of altered GR function …

Increasing evidence suggests that depression is characterised by impaired brain plasticity
that might originate from the interaction between genetic and environmental risk factors …

The aim of this study was to investigate whether conditional inactivation of the glucocorticoid
receptors (GRs) in noradrenergic neurons affects animal behavior in mice. Selective …