Comparative secretome analyses of primary murine white and brown adipocytes reveal novel adipokines

AA Khan, J Hansson, P Weber, S Foehr… - Molecular & Cellular …, 2018 - ASBMB
The adipose organ, including white and brown adipose tissues, is an important player in
systemic energy homeostasis, storing excess energy in form of lipids while releasing energy …

Brown/Beige adipose tissues and the emerging role of their secretory factors in improving metabolic health: The batokines

B Ahmad, MS Vohra, MA Saleemi, CJ Serpell, IL Fong… - Biochimie, 2021 - Elsevier
Brown and beige adipose tissues are the primary sites for adaptive non-shivering
thermogenesis. Although they have been known principally for their thermogenic effects, in …

Proteomics-based comparative mapping of the secretomes of human brown and white adipocytes reveals EPDR1 as a novel batokine

AS Deshmukh, L Peijs, JL Beaudry, NZ Jespersen… - Cell Metabolism, 2019 - cell.com
Adipokines secreted from white adipose tissue play a role in metabolic crosstalk and
homeostasis, whereas the brown adipose secretome is less explored. We performed high …

Brown adipose tissue as an endocrine organ: updates on the emerging role of batokines

FF Martins, V Souza-Mello, MB Aguila… - … Molecular Biology and …, 2023 - degruyter.com
Brown adipose tissue (BAT) remains active in adults, oxidizing fatty acids or glucose and
releasing energy in the form of heat. Brown adipocytes and enhanced thermogenesis are …

Secretory proteome of brown adipocytes in response to cAMP-mediated thermogenic activation

J Villarroya, R Cereijo, M Giralt, F Villarroya - Frontiers in physiology, 2019 - frontiersin.org
Background: The secretory properties of brown adipose tissue are thought to contribute to
the association between active brown fat and a healthy metabolic status. Although a few …

Identification and validation of novel adipokines released from primary human adipocytes

S Lehr, S Hartwig, D Lamers, S Famulla… - Molecular & cellular …, 2012 - ASBMB
Adipose tissue is a major endocrine organ, releasing signaling and mediator proteins,
termed adipokines, via which adipose tissue communicates with other organs. Expansion of …

Advances in the understanding of adipose tissue biology

S Kajimura - Nature reviews endocrinology, 2017 - nature.com
Adipose tissues have a central role in energy homeostasis, as they secrete adipokines and
regulate energy storage and dissipation. Novel adipokines from white, brown and beige …

Proteomic characterization of adipose tissue constituents, a necessary step for understanding adipose tissue complexity

JR Peinado, M Pardo, O de la Rosa, MM Malagón - Proteomics, 2012 - Wiley Online Library
The original concept of adipose tissue as an inert storage depot for the excess of energy has
evolved over the last years and it is now considered as one of the most important organs …

Human adipocyte proteomics-a complementary way of looking at fat

YDC Halvorsen, WO Wilkison, MR Briggs - Pharmacogenomics, 2000 - Taylor & Francis
As little as 100 years ago, and for some of the world's population even today, starvation was
and is a predominant component of our nutritional state. Adipose evolved as an efficient …

Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders

S Lehr, S Hartwig, H Sell - PROTEOMICS–Clinical Applications, 2012 - Wiley Online Library
Adipose tissue is a major endocrine organ, releasing signaling and mediator proteins,
termed adipokines, via which adipose tissue communicates with other organs. Expansion of …