Tumor suppressor protein p19 ARF (Arf; p14 ARF in humans) functions in both p53-
dependent and-independent modes to counteract hyper-proliferative signals caused by …

The ARF tumor suppressor protein acts in a checkpoint that guards against unscheduled
cellular proliferation in response to oncogenic signaling. Deregulated expression of c-Myc …

ARF is a vital tumor suppressor and its loss contributes significantly to cancer. The frequency
in which ARF is mutated, deleted or silenced is second to the loss of p53. The most …

The tumor suppressor ARF inhibits cell growth in response to oncogenic stress in a p53-
dependent manner. Also, there is an increasing appreciation of ARF's ability to inhibit cell …

The p14ARF (ARF) tumour suppressor plays an important role in the cellular response to
oncogene activation. In this report, we demonstrate an interaction between ARF and DAXX …

The p19 ARF gene product responds to oncogenic stresses by interfering with the inhibitory
effects of Mdm2 on p53, thus enhancing p53 activity and its antiproliferative functions. The …

Mammalian cells that sustain oncogenic insults can invoke defensive programmes that
either halt their division or trigger their apoptosis, but these countermeasures must be finely …

The nucleolar Arf protein has been shown to regulate cell cycle through both p53-dependent
and-independent pathways. In addition to the well-characterized Arf-mdm2-p53 pathway …

Until recently, the ability of ARF (human p14 ARF, murine p19 ARF) tumour-suppressor
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …

The tumor suppressor protein ARF (alternate reading frame) inhibits MDM2 to stabilize and
activate the functions of p53. Here we provide evidence for an additional activity of ARF that …