A heterometallic ruthenium–gold complex displays antiproliferative, antimigratory, and antiangiogenic properties and inhibits metastasis and angiogenesis-associated …
Heterobimetallic compounds are designed to harness chemotherapeutic traits of distinct
metal species into a single molecule. The ruthenium–gold (Ru–Au) family of compounds …
metal species into a single molecule. The ruthenium–gold (Ru–Au) family of compounds …
Ru (II)‐based antineoplastic: A “wingtip” N‐heterocyclic carbene facilitates access to a new class of organometallics that are cytotoxic to common cancer cell lines
A Mondal, RK Tripathy, P Dutta… - Applied …, 2019 - Wiley Online Library
The syntheses, structures, and chemotherapeutic activities of Ag (I)‐, Au (I)‐, and Ru (II)‐
complexes ligated to a novel N‐heterocyclic carbene ligand, 2‐(4‐nitrophenyl) imidazo [1, 5 …
complexes ligated to a novel N‐heterocyclic carbene ligand, 2‐(4‐nitrophenyl) imidazo [1, 5 …
Versatile synthesis of cationic N-heterocyclic carbene–gold (I) complexes containing a second ancillary ligand. Design of heterobimetallic ruthenium–gold anticancer …
J Fernández-Gallardo, BT Elie, M Sanaú… - Chemical …, 2016 - pubs.rsc.org
We describe a versatile and quick route to cationic gold (I) complexes containing N-
heterocyclic carbenes and a second ancillary ligand (such as phosphanes, phosphites …
heterocyclic carbenes and a second ancillary ligand (such as phosphanes, phosphites …
Combination of ruthenium(II)-arene complex [Ru(η6-p-cymene)Cl2(pta)] (RAPTA-C) and the epidermal growth factor receptor inhibitor erlotinib results in efficient …
RH Berndsen, A Weiss, UK Abdul, TJ Wong… - Scientific reports, 2017 - nature.com
Ruthenium-based compounds show strong potential as anti-cancer drugs and are being
investigated as alternatives to other well-established metal-based chemotherapeutics. The …
investigated as alternatives to other well-established metal-based chemotherapeutics. The …
Heterometallic titanium–gold complexes inhibit renal cancer cells in vitro and in vivo
J Fernández-Gallardo, BT Elie, T Sadhukha… - Chemical …, 2015 - pubs.rsc.org
Following recent work on heterometallic titanocene–gold complexes as potential
chemotherapeutics for renal cancer, we report here on the synthesis, characterization and …
chemotherapeutics for renal cancer, we report here on the synthesis, characterization and …
Novel ruthenium (II) and gold (I) NHC complexes: Synthesis, characterization, and evaluation of their anticancer properties
F Hackenberg, H Müller-Bunz, R Smith… - …, 2013 - ACS Publications
The synthesis, characterization, and biological evaluation of novel Ru (II)-and Au (I)-N-
heterocyclic carbenes is reported. The NHC-ruthenium (II) complexes (1–6) were …
heterocyclic carbenes is reported. The NHC-ruthenium (II) complexes (1–6) were …
Anticancer Gold N‐Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study
N Estrada‐Ortiz, F Guarra, IAM de Graaf… - …, 2017 - Wiley Online Library
A series of organometallic AuI N‐heterocyclic carbene (NHC) complexes was synthesized
and characterized for anticancer activity in four human cancer cell lines. The compounds' …
and characterized for anticancer activity in four human cancer cell lines. The compounds' …
Organometallic ruthenium-based antitumor compounds with novel modes of action
Both metal complexes and organic molecules are widely used for the treatment of various
diseases including cancer–in addition to surgery and radiotherapy. Recent years have …
diseases including cancer–in addition to surgery and radiotherapy. Recent years have …
Gold (I) NHC-based homo-and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents
B Bertrand, A Citta, IL Franken, M Picquet… - JBIC Journal of …, 2015 - Springer
While N-heterocyclic carbenes (NHC) are ubiquitous ligands in catalysis for organic or
industrial syntheses, their potential to form transition metal complexes for medicinal …
industrial syntheses, their potential to form transition metal complexes for medicinal …
Cytotoxic Gold (I) N‐heterocyclic Carbene Complexes with Phosphane Ligands as Potent Enzyme Inhibitors
R Rubbiani, L Salassa, A De Almeida… - …, 2014 - Wiley Online Library
Organometallic gold complexes with N‐heterocyclic carbene (NHC) ligands have been
demonstrating promising properties as novel anticancer agents. Gold (I) NHC complexes …
demonstrating promising properties as novel anticancer agents. Gold (I) NHC complexes …
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