A heterometallic ruthenium–gold complex displays antiproliferative, antimigratory, and antiangiogenic properties and inhibits metastasis and angiogenesis-associated …

BT Elie, Y Pechenyy, F Uddin, M Contel - JBIC Journal of Biological …, 2018 - Springer
Heterobimetallic compounds are designed to harness chemotherapeutic traits of distinct
metal species into a single molecule. The ruthenium–gold (Ru–Au) family of compounds …

Ru (II)‐based antineoplastic: A “wingtip” N‐heterocyclic carbene facilitates access to a new class of organometallics that are cytotoxic to common cancer cell lines

A Mondal, RK Tripathy, P Dutta… - Applied …, 2019 - Wiley Online Library
The syntheses, structures, and chemotherapeutic activities of Ag (I)‐, Au (I)‐, and Ru (II)‐
complexes ligated to a novel N‐heterocyclic carbene ligand, 2‐(4‐nitrophenyl) imidazo [1, 5 …

Versatile synthesis of cationic N-heterocyclic carbene–gold (I) complexes containing a second ancillary ligand. Design of heterobimetallic ruthenium–gold anticancer …

J Fernández-Gallardo, BT Elie, M Sanaú… - Chemical …, 2016 - pubs.rsc.org
We describe a versatile and quick route to cationic gold (I) complexes containing N-
heterocyclic carbenes and a second ancillary ligand (such as phosphanes, phosphites …

Combination of ruthenium(II)-arene complex [Ru(η6-p-cymene)Cl2(pta)] (RAPTA-C) and the epidermal growth factor receptor inhibitor erlotinib results in efficient …

RH Berndsen, A Weiss, UK Abdul, TJ Wong… - Scientific reports, 2017 - nature.com
Ruthenium-based compounds show strong potential as anti-cancer drugs and are being
investigated as alternatives to other well-established metal-based chemotherapeutics. The …

Heterometallic titanium–gold complexes inhibit renal cancer cells in vitro and in vivo

J Fernández-Gallardo, BT Elie, T Sadhukha… - Chemical …, 2015 - pubs.rsc.org
Following recent work on heterometallic titanocene–gold complexes as potential
chemotherapeutics for renal cancer, we report here on the synthesis, characterization and …

Novel ruthenium (II) and gold (I) NHC complexes: Synthesis, characterization, and evaluation of their anticancer properties

F Hackenberg, H Müller-Bunz, R Smith… - …, 2013 - ACS Publications
The synthesis, characterization, and biological evaluation of novel Ru (II)-and Au (I)-N-
heterocyclic carbenes is reported. The NHC-ruthenium (II) complexes (1–6) were …

Anticancer Gold N‐Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study

N Estrada‐Ortiz, F Guarra, IAM de Graaf… - …, 2017 - Wiley Online Library
A series of organometallic AuI N‐heterocyclic carbene (NHC) complexes was synthesized
and characterized for anticancer activity in four human cancer cell lines. The compounds' …

Organometallic ruthenium-based antitumor compounds with novel modes of action

WH Ang, A Casini, G Sava, PJ Dyson - Journal of Organometallic Chemistry, 2011 - Elsevier
Both metal complexes and organic molecules are widely used for the treatment of various
diseases including cancer–in addition to surgery and radiotherapy. Recent years have …

Gold (I) NHC-based homo-and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents

B Bertrand, A Citta, IL Franken, M Picquet… - JBIC Journal of …, 2015 - Springer
While N-heterocyclic carbenes (NHC) are ubiquitous ligands in catalysis for organic or
industrial syntheses, their potential to form transition metal complexes for medicinal …

Cytotoxic Gold (I) N‐heterocyclic Carbene Complexes with Phosphane Ligands as Potent Enzyme Inhibitors

R Rubbiani, L Salassa, A De Almeida… - …, 2014 - Wiley Online Library
Organometallic gold complexes with N‐heterocyclic carbene (NHC) ligands have been
demonstrating promising properties as novel anticancer agents. Gold (I) NHC complexes …