The β-amyloid protein (Aβ) is the major component of senile plaques found in the brain in
Alzheimer's disease (AD). Its neurotoxic properties in vivo, however, are not well defined …

Brain-derived neurotrophic factor (BDNF) has been suggested to be involved in memory
processes. In the present study, the association between memory impairment at senescence …

Evidence from human neuropathological studies indicates that the levels of the
neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are …

Neurotrophins, including brain‐derived neurotrophic factor (BDNF), nerve growth factor
(NGF), and neurotrophin‐3 (NT‐3), have repeatedly been shown to be involved in the …

Downregulation of brain-derived neurotrophic factor (BDNF) in the cortex occurs early in the
progression of Alzheimer's disease (AD). Since BDNF plays a critical role in neuronal …

Beta-amyloid (Aβ) deposition is one important pathological hallmark in Alzheimer's disease
(AD). However, low levels of Aβ may modify critical endogenous protection systems before …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by extracellular
accumulation of amyloid deposits and intracellular neurofibrillary tangles (NFT) composed of …

In recent years, nerve growth factor (NGF) has gained attention as a potential therapeutic
agent for Alzheimer's disease (AD). To study the expression of NGF and its homologs, brain …

We examined the potential protective effect of BDNF against β-amyloid-induced
neurotoxicity in vitro and in vivo in rats. In neuronal cultures, BDNF had specific and dose …

Accumulating evidences demonstrated that epigenetic modification of the expression of
specific genes contributed to the pathogenesis of neurological disorders with dementia …