A combination of antiplatelet drugs with high-intensity statin therapy is a standard in patients
with coronary events. Concomitant treatment with ticagrelor, a moderate CYP3A4 inhibitor …

Introduction Drug–drug interactions with cyclin-dependent kinases inhibitors 4 and 6
(CDK4/6) are known and should be taken into account. Case report A 68-year-old woman …

Objective: To assess the frequency of risk factors for rhabdomyolysis with simvastatin and
atorvastatin in cases reported to the Australian Adverse Drug Reactions Advisory Committee …

Rhabdomyolysis is a serious adverse drug reaction of statins. There are few studies
comparing the risk of rhabdomyolysis between the different statins. Using the WHO …

Statins are widely used in the treatment of hyperlipidaemia. Common side effects associated
with statin therapy include headache, gastrointestinal symptoms and musculoskeletal …

Statins are an established class of drugs with proven efficacy in cardiovascular risk
reduction. The concern over statin safety was first raised with the revelation of myopathy and …

Background: Myopathy is one of the most common adverse reactions of daptomycin and
statins. We aimed to evaluate the muscular toxicity of the combination therapy of daptomycin …

Background: Simvastatin, a 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitor, is
indicated for the treatment of hypercholesterolemia and plays an important role in both the …

Background Statins have a well-established role in prevention of vascular events but are
associated with muscle-related adverse events. The dose relationship with these adverse …

OBJECTIVE: To report a case of rhabdomyolysis and acute hepatitis associated with the
coadministration of atorvastatin and diltiazem. CASE SUMMARY: A 60-year-old African …