Neutrophil elastase (NE), a serine protease released from the azurophil granules of
activated neutrophil, proteolytically cleaves multiple cytokines, and cell surface proteins. In …

Neovascularization by sprouting angiogenesis is critical for inflammation-mediated tissue
remodeling and wound healing. We report here that human polymorphonuclear neutrophils …

The effects of the angiogenic factors basic fibroblast growth factor (bFGF) and vascular
endothelial growth factor (VEGF) on human polymorphonuclear leukocyte (PMNL) …

Increasing data from the literature point to a neutrophil-mediated role via cytokine production
in several aspects of mammalian biology, including angiogenesis. In such regard …

Elastase released from neutrophils as part of the innate immune system has been implicated
in chronic diseases such as emphysema and cardiovascular disease. We have previously …

Background Vascular endothelial growth factor (VEGF; vascular permeability factor) is one
of the most potent proangiogenic cytokines, and it plays a central role in mediating the …

Mature neutrophils are able to regulate several aspects of the immune response; their
influence extends beyond innate immunity, as they can modify lymphocyte maturation and …

Rapid regrowth or recurrent growth of occult cancer cells are often observed after
esophagectomy or postoperative complications. In order to clarify the mechanism of such …

Background. The role of neutrophils in angiogenesis remains largely unknown. Recent
evidence has shown that polymorphonuclear neutrophils (PMNs) produce several …

Background—Catabolism of the extracellular matrix (ECM) contributes to vascular
remodeling in health and disease. Although metalloenzymes and cysteinyl proteinases have …