Nasopharyngeal carcinoma (NPC), the most frequent reason for treatment failure in head
and neck tumors, has the greatest incidence of distant metastases. Increased vascular …

Cancer-cell-released exosomal microRNAs (miRNAs) are important mediators of cell-cell
communication in the tumor microenvironment. In this study, we sequenced serum exosome …

Abstract Background Both microRNA-21-5p (miR-21) and the tumor microenvironment,
including hypoxia and cancer-associated fibroblasts (CAFs), play a vital role in head and …

Hypoxia is a common feature of solid tumors and is associated with aggressiveness and
poor patient outcomes. Exosomes, initially considered to be cellular “garbage dumpsters,” …

Background Exosomes have emerged as critical mediators of intercellular communication.
Hypoxia is widely recognized as a key regulator of tumor aggressiveness, and significantly …

Glioblastoma (GBM) is the most lethal primary brain tumor and has a complex molecular
profile. Hypoxia plays a critical role during tumor progression and in the tumor …

Background Intratumor heterogeneity is common in cancers, with different cell subtypes
supporting each other to become more malignant. Nasopharyngeal carcinoma (NPC), a …

Hypoxia plays a critical role during the evolution of malignant cells and tumour
microenvironment (TME). Tumour-derived exosomes contain informative microRNAs …

The invasion-metastasis cascade in head and neck squamous cell carcinoma (HNSCC) is
predominantly caused by the interaction between tumor cells and tumor microenvironment …

Background Exosomes are small vesicles containing a wide range of functional proteins,
mRNA and miRNA. Exosomal miRNAs from cancer cells play crucial roles in mediating cell …