Many advanced cancers receive cisplatin‐based chemotherapy. However, cisplatin
resistance is a major obstacle for cancer chemotherapy. Foxo3a is a member of the Foxo …

Cisplatin is one of the major chemotherapeutic agents used against different human
cancers. A better understanding of the downstream cellular targets of cisplatin will provide …

Cisplatin is a conventional chemotherapeutic agent that binds covalently to purine DNA
bases and mediates cellular apoptosis. A better understanding of the downstream cellular …

FoxO proteins (FoxOs) are transcription factors with a common DNA binding domain that
confers selectivity for DNA interaction. In human cells, four proteins (FoxO1, FoxO3, FoxO4 …

Background Cisplatin (CDDP) is one of the most important chemotherapeutic agents in the
treatment of advanced gastric cancer, but its efficacy is limited by CDDP resistance. Because …

FOXO transcription factors, functioning downstream of the PI3K-PTEN-AKT (PKB) signalling
cascade, are essential for cell proliferation, differentiation, DNA damage repair and …

FOXO transcription factors promote cell cycle arrest, apoptosis, DNA damage repair and
detoxification of reactive oxygen species by regulating specific gene setting. As FOXO …

The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation,
progression, and drug resistance. Recent research shows that FOXM1 is a direct …

Cancer is one of the major causes of death and a significant obstacle to increasing life
expectancy worldwide. Chemotherapy remains the first-line adjuvant therapeutic option for …

Low sensitivity to chemotherapy has been a major challenge in the treatment of non-small-
cell lung cancer (NSCLC). It is of great clinical significance to discover its mechanisms to …