Chemotherapy-induced neutropenia is one of the major adverse events which results in the
reduction of chemotherapy. Doxorubicin is a substrate of the adenosine triphosphate …

The sequencing of the human genome has allowed the identification of thousands of gene
polymorphisms, most often single nucleotide polymorphims (SNP), which may play an …

The cytochromes P450 (CYPs) are key enzymes in cancer formation and cancer treatment.
They mediate the metabolic activation of numerous precarcinogens and participate in the …

Purpose The clinical efficacy of tamoxifen is suspected to be influenced by the activity of
drug-metabolizing enzymes and transporters involved in the formation, metabolism, and …

Though current knowledge of pharmacogenetic factors relevant to drug metabolism is fairly
comprehensive and this should facilitate translation to the clinic, there are a number of gaps …

CYP2D6 plays a major role in the metabolism of tamoxifen, and polymorphism of P-
glycoprotein has been associated with resistance of many drug therapies. This study …

The term “pharmacogenetics” is used to describe the study of variability in drug response
due to heredity. It is associated with “gene–drug interactions”. Later on, the term …

Polymorphic genes of drug metabolizing enzymes and transporters may influence drug
response. With some exemptions, single nucleotide polymorphisms in such genes, however …

Interindividual differences of drug response are an important cause of treatment failures and
adverse drug reactions. The identification of polymorphisms explaining distinct phenotypes …

Abstract Learning Objectives After completing this course, the reader will be able to: Explain
how genetic factors contribute to variability in drug response. Apply this understanding to …