Pancreatic cancer is a highly malignant cancer and lacks effective therapeutic targets.
Protein-tyrosine phosphatase 1B (PTP1B), a validated therapeutic target for diabetes and …

Objective This study conducted a comprehensive analysis of the members of the PTPN
family and emphasized the key role of PTPN2 as a potential therapeutic target and …

Protein tyrosine phosphorylation is one of the major post-translational modifications in
eukaryotic cells and represents a critical regulatory mechanism of a wide variety of signaling …

PTP1B is a classical non-transmembrane protein tyrosine phosphatase that plays a key role
in metabolic signaling and is a promising drug target for type 2 diabetes and obesity …

Ovarian cancer, which is the leading cause of death from gynecological malignancies, is a
heterogeneous disease known to be associated with disruption of multiple signaling …

The protein tyrosine phosphatase PTP 1B, which is encoded by PTPN 1, is a ubiquitously
expressed nonreceptor protein tyrosine phosphatase. PTP 1B has long been known to …

In cancer, kinases are often activated and phosphatases suppressed, leading to aberrant
activation of signaling pathways driving cellular proliferation, survival, and therapeutic …

Protein tyrosine phosphatase 1B (PTP1B) is a well-known inhibitor of insulin signaling
pathways and inhibitors against PTP1B are being developed as promising drug candidates …

Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the insulin signalling
pathway. It has been demonstrated that PTP1B deletion protects against the development of …

The protein tyrosine phosphatase 1B (PTP1B), a non-transmembrane protein tyrosine
phosphatase, has been implicated in gastric pathogenesis. Several lines of recent …