From intramuscular to nasal: unleashing the potential of nasal spray vaccines against coronavirus disease 2019

G Jin, R Wang, Y Jin, Y Song… - Clinical & Translational …, 2024 - Wiley Online Library
Coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2
(SARS‐CoV‐2), has affected 700 million people worldwide since its outbreak in 2019. The …

Intranasal COVID-19 vaccines: From bench to bed

A Alu, L Chen, H Lei, Y Wei, X Tian, X Wei - EBioMedicine, 2022 - thelancet.com
Currently licensed COVID-19 vaccines are all designed for intramuscular (IM) immunization.
However, vaccination today failed to prevent the virus infection through the upper respiratory …

COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges

K Dhama, M Dhawan, R Tiwari, TB Emran… - Human vaccines & …, 2022 - Taylor & Francis
Multiple vaccines have recently been developed, and almost all the countries are presently
vaccinating their population to tackle the COVID-19 pandemic. Most of the COVID-19 …

[HTML][HTML] Nasal vaccine as a booster shot: a viable solution to restrict pandemic?

S Meenakshi, VU Kumar, S Dhingra… - Clinical and Experimental …, 2022 - ncbi.nlm.nih.gov
Abstract The coronavirus disease 2019 (COVID-19) pandemic revolutionized the vaccine
market and initiated the momentum for alternative routes of administration for vaccines. The …

Intranasal vaccines for SARS-CoV-2: From challenges to potential in COVID-19 management

VP Chavda, LK Vora, AK Pandya, VB Patravale - Drug discovery today, 2021 - Elsevier
Abstract Unlike conventional Coronavirus 2019 (COVID-19) vaccines, intranasal vaccines
display a superior advantage because the nasal mucosa is often the initial site of infection …

Nasal vaccination against SARS-CoV-2: Synergistic or alternative to intramuscular vaccines?

M Tiboni, L Casettari, L Illum - International journal of pharmaceutics, 2021 - Elsevier
It is striking that all marketed SARS-CoV-2 vaccines are developed for intramuscular
administration designed to produce humoral and cell mediated immune responses …

Development and challenges of nasal spray vaccines for short-term COVID-19 protection

J Xi - Current Pharmaceutical Biotechnology, 2022 - ingentaconnect.com
For those who have traveled by flight during this pandemic and been seated in a packed
cabin for an extended period, it is natural to worry about the elevated risk of COVID-19 …

Oral and intranasal vaccines against SARS‐CoV‐2: Current progress, prospects, advantages, and challenges

S Kar, P Devnath, TB Emran, TE Tallei… - Immunity …, 2022 - Wiley Online Library
Background The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has
caused a deadly pandemic in the 21st century, resulting in many deaths, economic loss, and …

Intranasal (IN) COVID-19 vaccines-a breakthrough

RS Gambhir, K Kaur, R Matariya, B Singh… - Roczniki …, 2023 - agro.icm.edu.pl
Emerging variants of COVID-19 have threatened the effectiveness of intramuscular (IM)
vaccines since that are made to target only the spike protein. Development of Intranasal (IN) …

An intranasal OMV-based vaccine induces high mucosal and systemic protecting immunity against a SARS-CoV-2 infection

PA van der Ley, A Zariri, E van Riet… - Frontiers in …, 2021 - frontiersin.org
The development of more effective, accessible, and easy to administer COVID-19 vaccines
next to the currently marketed mRNA, viral vector, and whole inactivated virus vaccines is …