The effects of quinidine, quinine, aspirin, ibuprofen, indomethacin and acetaminophen on
steady state serum digoxin concentrations and total body digoxin clearance were studied in …

The effect of diltiazem on digoxin serum concentration was evaluated in 9 patients who had
been treated chronically for heart disease with digoxin, 0.25 mg/day. The indications for …

Digoxin concentrations in serum, myocardium, 3 separate skeletal muscles, kidney, liver,
and 5 sites in the brain were measured in 26 dogs given 12-alpha 3 H-digoxin. Ten of the …

The time course of the rise in serum digoxin concentration was followed in 18 patients
treated with digoxin as quinidine treatment was started with a loading dose. The mean …

Seven healthy volunteers received a single 1.0‐mg dose of intravenous digoxin in a drug‐
free control trial and again during concurrent therapy with therapeutic doses of quinidine …

Drug interactions with digoxin are being increasingly recognized. Some calcium antagonists
have been shown to alter digoxin kinetics and changes in digoxin dosage have been …

Quinidine elevates serum digoxin concentration in part by reducing the volume of
distribution of digoxin, which implies that quinidine displaces digoxin from tissues. The …

About 70 to 80% of an oral dose of digoxin is absorbed, mainly in the proximal part of the
small intestine. The degree of binding to serum albumin is 20 to 30%. Digoxin is extensively …

Nine healthy male volunteers received single 0.5, 1.0, and 1.5 mg. doses of intravenous
digoxin in a randomized three-way crossover study. Multiple venous blood samples were …

Digoxin has been associated with a variety of drug interactions. Studies in our laboratory
indicate that single doses of prazosin may alter plasma steady-state digoxin levels. Adult …