MicroRNA miR-223 as regulator of innate immunity

X Yuan, N Berg, JW Lee, TT Le… - Journal of leukocyte …, 2018 - academic.oup.com
MicroRNAs were discovered more than 2 decades ago and have profound impact on
diverse biological processes. Specific microRNAs have important roles in modulating the …

miR-223: an immune regulator in infectious disorders

S Yuan, Q Wu, Z Wang, Y Che, S Zheng… - Frontiers in …, 2021 - frontiersin.org
MicroRNAs (miRNAs) are diminutive noncoding RNAs that can influence disease
development and progression by post-transcriptionally regulating gene expression. The anti …

[HTML][HTML] miR-223: an effective regulator of immune cell differentiation and inflammation

P Jiao, XP Wang, ZM Luoreng, J Yang… - … Journal of Biological …, 2021 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) play a critical role in regulating various biological processes, such as
cell differentiation and immune modulation by binding to their target genes. miR-223 is a …

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

V Neudecker, M Haneklaus, O Jensen… - Journal of Experimental …, 2017 - rupress.org
MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how
miRNA circuits orchestrate aberrant intestinal inflammation during inflammatory bowel …

The emerging role of miR-223 as novel potential diagnostic and therapeutic target for inflammatory disorders

F Aziz - Cellular immunology, 2016 - Elsevier
Since their discovery of more than a decade ago, microRNAs have been demonstrated to
have profound effects on almost every aspect of biology. Specific microRNAs have emerged …

[PDF][PDF] MicroRNA-223 suppresses the canonical NF-κB pathway in basal keratinocytes to dampen neutrophilic inflammation

W Zhou, AS Pal, AYH Hsu, T Gurol, X Zhu… - Cell reports, 2018 - cell.com
MicroRNA-223 is known as a myeloid-enriched anti-inflammatory microRNA that is
dysregulated in numerous inflammatory conditions. Here, we report that neutrophilic …

Role of miR-223 in the pathophysiology of liver diseases

D Ye, T Zhang, G Lou, Y Liu - Experimental & molecular medicine, 2018 - nature.com
MiRNAs are small, noncoding RNAs, which can regulate gene expression
posttranscriptionally, and they have emerged as key factors in disease biology by aiding in …

[HTML][HTML] MiR-146 and miR-125 in the regulation of innate immunity and inflammation

HM Lee, TS Kim, EK Jo - BMB reports, 2016 - ncbi.nlm.nih.gov
Innate immune responses are primary, relatively limited, and specific responses to
numerous pathogens and toxic molecules. Protein expression involved in these innate …

The many facets of miR‐223 in cancer: oncosuppressor, oncogenic driver, therapeutic target, and biomarker of response

A Favero, I Segatto, T Perin… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
Given their intrinsic pleiotropism, microRNAs (miR) play complex biological roles, in both
normal and pathological conditions. Often the same miR can act as oncogene or …

[HTML][HTML] miR-223: a key regulator in the innate immune response in asthma and COPD

MP Roffel, KR Bracke, IH Heijink, T Maes - Frontiers in medicine, 2020 - frontiersin.org
Asthma and Chronic Obstructive Pulmonary Disease (COPD) are chronic obstructive
respiratory diseases characterized by airway obstruction, inflammation, and remodeling …