Inhibition of receptor-coupled adenylate cyclase by hormones is proposed to be associated
with GTP hydrolysis. Since adenosine inhibits cerebral-cortical adenylate cyclase via A1 …

Adenosine analogues inhibit rat cerebral cortical adenylate cyclase by a receptor-mediated
GTP-dependent process. N 6-Phenylisopropyladenosine and other analogues of adenosine …

Two adenosine receptor sites have been detected in striatal homogenates. One triggered
the stimulation and the other the inhibition of the adenylate cyclase. They clearly had …

An adenosine‐sensitive adenylate cyclase has been characterized from rat brain striatum. In
whole homogenates as well as in particulate fractions, N6‐phenylisopropyl adenosine (PIA) …

In order to investigate the functional interaction between adenosine receptors and G-
proteins in native brain membranes, stimulation of high-affinity GTPase activity by adenosine …

The effect of increasing doses of GTP on agonist and antagonist binding to adenosine A1-
receptors in different regions of rat brain was studied by autoradiography. A high …

Signal transduction by A1 adenosine receptors was investigated by measuring the
modulation by adenosine agonists of guanosine-5'-O-(3-[35S] thio) triphosphate ([35S] GTP …

Methylisoguanosine, a marine natural product with potent muscle-relaxant and
cardiovascular actions in vivo, interacts directly with adenosine receptors in guinea-pig brain …

In cellular systems provided with activatory (Ra-site) receptors for adenosine, such as rat
cerebral microvessels and rat liver plasma membranes, the adenosine-receptor antagonist 8 …

When tested under conditions reducing the endogenous production of adenosine (presence
of adenosine deaminase (ADA) 1.6 IU/ml; and deoxyadenosine triphosphate (d-ATP)), and …