Variation in the OC Locus of Acinetobacter baumannii Genomes Predicts Extensive Structural Diversity in the Lipooligosaccharide

JJ Kenyon, SJ Nigro, RM Hall - PloS one, 2014 - journals.plos.org
Lipooligosaccharide (LOS) is a complex surface structure that is linked to many pathogenic
properties of Acinetobacter baumannii. In A. baumannii, the genes responsible for the …

Identification of further variation at the lipooligosaccharide outer core locus in Acinetobacter baumannii genomes and extension of the OCL reference sequence …

BM Sorbello, SM Cahill, JJ Kenyon - Microbial Genomics, 2023 - microbiologyresearch.org
The outer core locus (OCL) that includes genes for the synthesis of the variable outer core
region of the lipooligosaccharide (LOS) is one of the key epidemiological markers used for …

[HTML][HTML] Insertions in the OCL1 locus of Acinetobacter baumannii lead to shortened lipooligosaccharides

JJ Kenyon, KE Holt, D Pickard, G Dougan… - Research in …, 2014 - Elsevier
Genomes of 82 Acinetobacter baumannii global clones 1 (GC1) and 2 (GC2) isolates were
sequenced and different forms of the locus predicted to direct synthesis of the outer core …

Updated analysis of the surface carbohydrate gene clusters in a diverse panel of Acinetobacter baumannii isolates

JJ Kenyon, RM Hall - Antimicrobial Agents and Chemotherapy, 2022 - Am Soc Microbiol
To enhance the utility of the genetically diverse panel of Acinetobacter baumannii isolates
reported recently by Galac and coworkers (MR Galac, E. Snesrud, F. Lebreton, J. Stam, et …

An update to the database for Acinetobacter baumannii capsular polysaccharide locus typing extends the extensive and diverse repertoire of genes found at and …

SM Cahill, RM Hall, JJ Kenyon - Microbial Genomics, 2022 - microbiologyresearch.org
Several novel non-antibiotic therapeutics for the critical priority bacterial pathogen,
Acinetobacter baumannii, rely on specificity to the cell-surface capsular polysaccharide …

Identification of Acinetobacter baumannii loci for capsular polysaccharide (KL) and lipooligosaccharide outer core (OCL) synthesis in genome assemblies using curated …

KL Wyres, SM Cahill, KE Holt, RM Hall… - Microbial …, 2019 - microbiologyresearch.org
Multiply antibiotic-resistant Acinetobacter baumannii infections are a global public health
concern and accurate tracking of the spread of specific lineages is needed. Variation in the …

Variation in the Complex Carbohydrate Biosynthesis Loci of Acinetobacter baumannii Genomes

JJ Kenyon, RM Hall - PloS one, 2013 - journals.plos.org
Extracellular polysaccharides are major immunogenic components of the bacterial cell
envelope. However, little is known about their biosynthesis in the genus Acinetobacter …

Rapid replacement of Acinetobacter baumannii strains accompanied by changes in lipooligosaccharide loci and resistance gene repertoire

MD Adams, MS Wright, JK Karichu, P Venepally… - MBio, 2019 - Am Soc Microbiol
The population structure of health care-associated pathogens reflects patterns of
diversification, selection, and dispersal over time. Empirical data detailing the long-term …

Phylogenomics of two ST1 antibiotic-susceptible non-clinical Acinetobacter baumannii strains reveals multiple lineages and complex evolutionary history in global …

J Koong, C Johnson, R Rafei, M Hamze… - Microbial …, 2021 - microbiologyresearch.org
Acinetobacter baumannii is an opportunistic pathogen that is difficult to treat due to its
resistance to extreme conditions, including desiccation and antibiotics. Most strains causing …

Problems with the Oxford multilocus sequence typing scheme for Acinetobacter baumannii: do sequence type 92 (ST92) and ST109 exist?

M Hamidian, SJ Nigro, RM Hall - Journal of Clinical Microbiology, 2017 - Am Soc Microbiol
Even in the genomic era, multilocus sequence typing (MLST) remains a method of choice for
bacterial typing, quickly revealing relationships within and between bacterial lineages …