Sphingosine 1-phosphate (S1P) signaling regulates numerous biological processes
including neurogenesis, inflammation and neovascularization. However, little is known …

Sphingosine 1-phosphate (S1P) is a bioactive lipid that is formed by the phosphorylation of
sphingosine by the enzyme, sphingosine kinase. S1P regulates cell function via a family of …

Sphingosine 1-phosphate (S1P) is a potent lipid mediator that modulates inflammation and
angiogenesis. In this study, we investigated the possible involvement of S1P in the …

The bioactive sphingolipid sphingosine-1-phosphate (S1P) acts as a ligand for a family of G
protein-coupled S1P receptors (S1PR1-5) to participate in a variety of signaling pathways …

Neovascular ocular diseases (such as age-related macular degeneration, diabetic
retinopathy and retinal vein occlusion) are characterised by common pathological processes …

Abstract Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid generated through
sphingosine kinase1 (SPK1)-mediated phosphorylation of sphingosine. We show here that …

Sphingosine 1–phosphate (S1P), a multifunctional lipid mediator that signals via the S1P
family of G protein–coupled receptors (S1PR), regulates vascular maturation, permeability …

Purpose: Neovascularization is a major cause of blindness in various ocular diseases.
Bioactive sphingosine 1-phosphate (S1P), synthesized by two sphingosine kinases (Sphk1 …

Abstract Sphingosine-1-phosphate (S1P) produced by sphingosine kinases (SPHK1 and
SPHK2) is a signaling molecule involved in cell proliferation and formation of cellular …

The sphingosine kinases 1 and 2 (SphK1 and 2) catalyze the phosphorylation of the lipid,
sphingosine, generating the signal transmitter, sphingosine 1-phosphate (S1P). The …