Molecular evolution of chronic myeloid leukaemia

PJ Shteper, D Ben-Yehuda - Seminars in cancer biology, 2001 - Elsevier
Chronic myeloid leukaemia (CML) is a clonal disorder of the pluripotent haematopoietic
stem cell. The typical triphasic course of CML starts with the premalignant chronic phase …

CML: mechanisms of disease initiation and progression

M Wetzler, M Talpaz, Z Estrov, R Kurzrock - Leukemia & lymphoma, 1993 - Taylor & Francis
Chronic myelogenous leukemia (CML) is a hematological stem cell disorder characterized
by excessive proliferation of the myeloid lineage. It has a progressive course typified by the …

Linkage of proliferative and maturational abnormalities in chronic myelogenous leukemia and relevance to treatment.

B Clarkson, A Strife - Leukemia, 1993 - europepmc.org
Despite recent advances in our understanding of the molecular and biological abnormalities
in chronic myelogenous leukemia (CML) this new knowledge has not yet led to significant …

Clonal evolution in chronic myelogenous leukemia

J Cortes, ME O'Dwyer - Hematology/Oncology Clinics, 2004 - hemonc.theclinics.com
Chronic myelogenous leukemia (CML) is a clonal hematopoietic stem cell disorder
characterized by a specific chromosomal translocation, t (9; 22), that results in a shortened …

Chronic myelogenous leukemia

BJ Druker - Principles of Molecular Medicine, 2006 - Springer
Chronic myelogenous leukemia is a clonal hematopoietic stem disorder characterized by
excess numbers of myeloid cells that over time, lose the capacity for terminal differentiation …

Chronic myeloid leukemia: pathophysiology, diagnostic parameters, and current treatment concepts

C Sillaber, M Mayerhofer, H Agis, V Sagaster… - Wiener Klinische …, 2003 - Springer
Chronic myeloid leukemia (CML) is a stem cell disease characterized by excessive
accumulation of clonal myeloid (precursor) cells in hematopoietic tissues. CML cells display …

Chronic myelogenous leukemia: update on biology and treatment.

S Faderl, HM Kantarjian, M Talpaz - Oncology (Williston Park, NY), 1999 - europepmc.org
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder that follows a
characteristic clinical course in which a chronic phase of variable duration precedes an …

The biology and pathogenesis of chronic myeloid leukemia

B Chereda, JV Melo - Chronic myeloid leukemia, 2016 - Springer
Chronic myeloid leukaemia (CML) is a myeloproliferative disorder of the haemopoietic stem
cell. Understanding the molecular biology of CML began with the discovery of the …

Chronic myelogenous leukemia: molecular and cellular aspects

G Pasternak, A Hochhaus, B Schultheis… - Journal of cancer …, 1998 - Springer
Chronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of
the bone marrow and is characterized by greatly increased numbers of granulocytes in the …

[PDF][PDF] Pathogenesis and progression of chronic myeloid leukemia

MA Santucci, G Saglio, S Tura - Haematologica, 1996 - haematologica.org
Haematologica 1996; 81: 63-76 sis of the level of bcr/abl rearrangement, transcription and
product within selected progenitor cell compartments is required for proper identification and …