Mitochondria, spermatogenesis, and male infertility–an update

S Vertika, KK Singh, S Rajender - Mitochondrion, 2020 - Elsevier
The incorporation of mitochondria in the eukaryotic cell is one of the most enigmatic events
in the course of evolution. This important organelle was thought to be only the powerhouse …

Mitochondria: their role in spermatozoa and in male infertility

M Boguenet, PE Bouet, A Spiers… - Human …, 2021 - academic.oup.com
BACKGROUND The best-known role of spermatozoa is to fertilize the oocyte and to transmit
the paternal genome to offspring. These highly specialized cells have a unique structure …

[HTML][HTML] Mitochondrial DNA mutations and male infertility

DP Kumar, N Sangeetha - Indian journal of human genetics, 2009 - ncbi.nlm.nih.gov
Infertility can be defined as difficulty in conceiving a child after 1 year of unprotected
intercourse. Infertility can arise either because of the male factor or female factor or both …

Causes and consequences of sperm mitochondrial dysfunction

D Durairajanayagam, D Singh, A Agarwal… - Andrologia, 2021 - Wiley Online Library
Mitochondria have multiple functions, including synthesis of adenine triphosphate,
production of reactive oxygen species, calcium signalling, thermogenesis and apoptosis …

Mitochondria, spermatogenesis and male infertility

S Rajender, P Rahul, AA Mahdi - Mitochondrion, 2010 - Elsevier
Mitochondria and its role in male reproduction has remained an enigma since long.
Similarly, etiology of male infertility in a large percentage of individuals, mainly primary …

Sperm mitochondria in reproduction: good or bad and where do they go?

SM Luo, H Schatten, QY Sun - Journal of Genetics and Genomics, 2013 - Elsevier
The mitochondrion is the major energy provider to power sperm motility. In mammals, aside
from the nuclear genome, mitochondrial DNA (mtDNA) also contributes to oxidative …

A role for mitochondrial DNA and sperm survival

JC St John, D Sakkas, CLR Barratt - Journal of Andrology, 2000 - discovery.dundee.ac.uk
This review outlines the role of mitochondria in providing energy for cell function and
discusses the relevance of mutations to various cell types within the mitochondrion's own …

Mitochondria functionality and sperm quality

A Amaral, B Lourenço, M Marques… - …, 2013 - rep.bioscientifica.com
Although mitochondria are best known for being the eukaryotic cell powerhouses, these
organelles participate in various cellular functions besides ATP production, such as calcium …

Mitochondria-related male infertility

K Nakada, A Sato, K Yoshida, T Morita… - Proceedings of the …, 2006 - National Acad Sciences
Approximately 15% of human couples are affected by infertility, and about half of these
cases of infertility can be attributed to men, through low sperm motility (asthenozoospermia) …

Mitochondrial functionality in male fertility: from spermatogenesis to fertilization

YJ Park, MG Pang - Antioxidants, 2021 - mdpi.com
Mitochondria are structurally and functionally distinct organelles that produce adenosine
triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to …