Objective To examine prognosis and risk factors for progression to and from secondary-
progressive multiple sclerosis (SPMS). Methods Patients with definite relapsing—remitting …

Background Similarities in the onset age of progression in secondary-progressive (SP) and
primary-progressive multiple sclerosis (PPMS) have been previously reported. However …

Background: The risk factors for conversion from relapsing-remitting to secondary
progressive multiple sclerosis remain highly contested. Objective: The aim of this study was …

Objective: To evaluate the clinical course of MS in individuals with onset of MS before age
16. Methods: Patients with onset of MS before age 16 (n= 116) with complete clinical …

We report a natural history study of 216 patients with primary progressive (PP)-multiple
sclerosis defined by at least 1 year of exacerbation-free progression at onset. This …

Background: It is unclear if all patients with relapsing–remitting multiple sclerosis (RRMS)
ultimately develop progressive MS. Onset of progressive disease course seems to be age …

Background: Recent natural history studies suggest that multiple sclerosis (MS) is a more
slowly progressing disease than previously thought. These observations are from studies …

Background The onset of secondary progression is a pivotal event in the course of relapsing–
remitting (RR) multiple sclerosis (MS). Patients with secondary progressive MS (SPMS) …

Objective To use the new consensus definitions of primary progressive multiple sclerosis
(PPMS) and progressive relapsing multiple sclerosis (PRMS) to report the demographic …

Objectives To investigate the relationship among attacks in the first 2 years (early relapses),
secondary progression (SP), and late disability in multiple sclerosis (MS). Design Cohort …