Importance Li-Fraumeni syndrome is a cancer predisposition syndrome that is associated
with a high, lifelong risk of a broad spectrum of cancers that is caused by …

Li-Fraumeni syndrome (LFS) is a rare dominantly inherited cancer predisposition syndrome
that was first described in 1969. In most families, it is caused by germline mutations in the …

Li–Fraumeni syndrome (LFS) is a complex hereditary cancer predisposition disorder
associated with early-onset cancers in diverse tissues of origin. Germline TP53 mutations …

Background: Li–Fraumeni syndrome is an autosomal dominant cancer predisposition
syndrome caused by germline mutations in the TP53 gene. The frequency of germline de …

Summary Background Li-Fraumeni syndrome, caused primarily by pathogenic or likely
pathogenic germline TP53 variants, is a rare, variably penetrant, cancer predisposition …

Background Li–Fraumeni syndrome (LFS) is a rare autosomal dominant cancer
predisposition syndrome. Most families fulfilling the classical diagnostic criteria harbour …

Li–Fraumeni syndrome (LFS) is an autosomal‐dominant cancer predisposition disorder
associated with pathogenic germline variants in TP53, with a high penetrance over an …

Abstract The Li–Fraumeni cancer predisposition syndrome is associated with germline TP53
mutations in the majority of families. We have investigated cancer incidence in 34 Li …

Germline pathogenic variants in TP53 gene have different consequences according to cell,
tissue, context and age. The occurrence of frequent variants in patients with no criteria …

Fifty years after the recognition of the Li–Fraumeni syndrome (LFS), our perception of
cancers related to germline alterations of TP53 has drastically changed:(i) germline TP53 …