Exosomes in cancer: small particle, big player

X Zhang, X Yuan, H Shi, L Wu, H Qian, W Xu - Journal of hematology & …, 2015 - Springer
Exosomes have emerged as a novel mode of intercellular communication. Exosomes can
shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs …

The roles of tumor‐derived exosomes in cancer pathogenesis

C Yang, PD Robbins - Journal of Immunology Research, 2011 - Wiley Online Library
Exosomes are endosome‐derived, 30–100 nm small membrane vesicles released by most
cell types including tumor cells. They are enriched in a selective repertoire of proteins and …

Extracellular vesicles remodel tumor environment for cancer immunotherapy

M Yue, S Hu, H Sun, B Tuo, B Jia, C Chen, W Wang… - Molecular Cancer, 2023 - Springer
Tumor immunotherapy has transformed neoplastic disease management, yet low response
rates and immune complications persist as major challenges. Extracellular vesicles …

Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases

TH Tran, G Mattheolabakis, H Aldawsari, M Amiji - Clinical immunology, 2015 - Elsevier
Abstract Cell secreted exosomes (30–100 nm vesicles) play a major role in intercellular
communication due to their ability to transfer proteins and nucleic acids from one cell to …

Engineered exosomes for studies in tumor immunology

A Alptekin, M Parvin, HI Chowdhury… - Immunological …, 2022 - Wiley Online Library
Exosomes are a type of extracellular vesicle (EV) with diameters of 30–150 nm secreted by
most of the cells into the extracellular spaces and can alter the microenvironment through …

Exosomes: a potential therapeutic tool targeting communications between tumor cells and macrophages

W Guo, Y Li, W Pang, H Shen - Molecular Therapy, 2020 - cell.com
Exosomes comprise extracellular vesicles (EVs) with diameters between 30 and 150 nm.
They transfer proteins, RNA, and other molecules from cell to cell, playing an important role …

Functions of cancer-derived extracellular vesicles in immunosuppression

L Czernek, M Düchler - Archivum immunologiae et therapiae …, 2017 - Springer
Extracellular vesicles, including exosomes, constitute an important element of intercellular
communication by carrying a variety of molecules from producer to target cells. The transport …

Tumor-derived exosomes in the cancer immune microenvironment and cancer immunotherapy

Q Tang, S Yang, G He, H Zheng, S Zhang, J Liu, S Wei… - Cancer letters, 2022 - Elsevier
Tumor-derived exosomes (TDEs) are key immune regulators in the tumor microenvironment.
They have been shown to reshape the immune microenvironment and prevent antitumor …

Modification of immune cell-derived exosomes for enhanced cancer immunotherapy: current advances and therapeutic applications

I Jung, S Shin, MC Baek, K Yea - Experimental & Molecular Medicine, 2024 - nature.com
Cancer immunotherapy has revolutionized the approach to cancer treatment of malignant
tumors by harnessing the body's immune system to selectively target cancer cells. Despite …

Macrophage-derived exosomes in cancers: Biogenesis, functions and therapeutic applications

J Liu, F Wu, H Zhou - Immunology Letters, 2020 - Elsevier
Macrophages are fundamental to promote tumorigenesis, tumor development and
metastasis, and chemotherapy resistance through modulating tumor microenvironment and …