Vitamin E, comprising tocopherols and tocotrienols, is mainly known as an antioxidant. The
aim of this review is to summarize the molecular mechanisms and signaling pathways linked …

With the advancement of in vivo studies and clinical trials, the pathogenesis of
neurodegenerative diseases has been better understood. However, gaps still need to be …

Vitamin E is the last of all vitamins whose essentiality is not yet understood. Its widely
accepted role as a lipophilic antioxidant has been questioned, since proof of its in vivo …

Introduction Vitamin E family, composed by tocopherols and tocotrienols, is a group of
compounds with neuroprotective properties. The exact role in the pathogenesis and the …

Since its discovery, vitamin E has been extensively researched by a large number of
investigators in an attempt to fully understand its role in a variety of pathophysiological …

Several pathological conditions are believed to be causally related to the generation of
reactive oxygen species and free radicals including various neurodegenerative disorders. In …

A hundred years have passed since vitamin E was identified as an essential micronutrient
for mammals. Since then, many biological functions of vitamin E have been unraveled in …

The vitamin E family consists of four tocopherols and four tocotrienols. α-Tocopherol (αT) is
the predominant form of vitamin E in tissues and its deficiency leads to ataxia in humans …

Vitamin E is an important antioxidant that primarily protects cells from damage associated
with oxidative stress caused by free radicals. The brain is highly susceptible to oxidative …

Several neurodegenerative disorders are associated with oxidative stress that is manifested
by lipid peroxidation, protein oxidation and other markers. Included in these disorders in …