Thrombospondin 1 and thrombospondin 2 (THBS1 and THBS2) share similar multifunctional
domains, and are known to be antiangiogenic. However, the expression pattern of THBS1 …

Recent cancer studies have found that the thrombospondin (THBS) family, including THBS1,
THBS2, THBS3, THBS4, and THBS5, play vital roles in the development and progression of …

Abstract Thrombospondin-2 (THBS2) is a secreted protein overexpressed in numerous
cancers and may function as a diagnostic tumor marker. The objective of the present study …

Abstract Background Thrombospondins (THBSs) are a family of multidomain and secreted
matricellular Ca 2+-binding glycoproteins which has at least five members encoded by …

Abstract Purpose: Thrombospondin 1 (THBS 1) is a matricellular protein capable of
modulating angiogenesis. However, the actual role of THBS 1 in angiogenesis and tumor …

Introduction Thrombospondin-4 is an extracellular glycoprotein involved in wound healing
and tissue remodeling. Although THBS4 is reportedly frequently expressed in solid tumors …

Purpose: To investigate the expression of thrombospondin 2 (THBS2) in colorectal cancer
(CRC) and its relationship with clinicopathological features and prognosis. Methods: THBS2 …

Thorombospondin-1 (TSP-1) is a 450 kDa extracellular matrix glycoprotein, with anti-
angiogenic activity. We analyzed the relationship in TSP-1 expression and Microvessel …

Purpose Thrombospondin 1 (THBS1) is an endogenous inhibitor of angiogenesis, but it also
promotes tumor invasion, metastasis, and immune response in the tumor environment …

Colorectal cancer (CRC) is the most common human digestive malignancy with a poor
prognosis; the pathophysiology of colon cancer involves multiple linkages of regulatory …