Background Demethylnobiletin (DN), with a variety of biological activities, is a polymethoxy‐
flavanone (PMF) found in citrus. In the present study, we explored the biological activities …

Nobiletin, a citrus polymethoxylated flavone, is reported to possess various pharmacological
activities such as anticancer, anti-inflammation, and antioxidant effects. Recently, nobiletin …

Background: Nobiletin (NOB), isolated from Citrus nobilis, has been reported to inhibit
cerebral ischemia/reperfusion (I/R) induced cell apoptosis in the brain. The mechanisms and …

Background Nobiletin (NOB), an active natural flavonoid component of citrus, is used in
Traditional Chinese Medicine for its anti-inflammatory activity, but its efficacy in cerebral …

Oxidative stress is considered to play an important role in the cerebral ischemia–reperfusion
injury. The nuclear transcription factor erythroid-2-related factor 2 (Nrf2)/NAD (P) H …

Diosmetin was found to exert protective effect on renal and myocardial ischemia‐reperfusion
(IR) injury. This study aimed to investigate the role of diosmetin in cerebral IR (CIR) injury …

Pharmacological or spontaneous thrombolysis in ischemic stroke triggers an outbreak of
reactive oxygen species and results in neuron death. Nrf2‐mediated antioxidation in cells …

Oxidative stress is considered a major contributing factor in cerebral ischemia/reperfusion
injury. Phloretin, a dihydrochalcone belonging to the flavonoid family, is particularly rich in …

Introduction Cerebral ischemic injury is associated with long-term disability.
Dexmedetomidine (Dex) can exert neuroprotective effects on cerebral ischemic/reperfusion …

Leonurine (Leo) has been found to have neuroprotective effects against cerebral ischemic
injury. However, the exact molecular mechanism underlying its neuroprotective ability …