Evidence for dendritic cell-dependent CD4+ T helper-1 type responses to commensal bacteria in normal human intestinal lamina propria
R Howe, S Dillon, L Rogers, M McCarter, C Kelly… - Clinical …, 2009 - Elsevier
Reactivity of lamina propria (LP) T cells to commensal bacteria has been demonstrated in
animal models of inflammatory bowel disease (IBD) and in humans with IBD, but few studies …
animal models of inflammatory bowel disease (IBD) and in humans with IBD, but few studies …
Cutting edge: generation of effector cells that localize to mucosal tissues and form resident memory CD8 T cells is controlled by mTOR
Mucosal tissues are subject to frequent pathogen exposure and are major sites for
transmission of infectious disease. CD8 T cells play a critical role in controlling mucosa …
transmission of infectious disease. CD8 T cells play a critical role in controlling mucosa …
[HTML][HTML] Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa
FR Kirchner, S LeibundGut-Landmann - Mucosal immunology, 2021 - Elsevier
Keeping a stable equilibrium between the host and commensal microbes to which we are
constantly exposed, poses a major challenge for the immune system. The host mechanisms …
constantly exposed, poses a major challenge for the immune system. The host mechanisms …
Probing CD8 T cell responses with Listeria monocytogenes infection
SA Condotta, MJ Richer, VP Badovinac… - Advances in immunology, 2012 - Elsevier
CD8 T cells play a critical role in the control and eradication of intracellular pathogens.
Increased understanding of CD8 T cell biology provides insight that can be translated into …
Increased understanding of CD8 T cell biology provides insight that can be translated into …
Microbial uptake in oral mucosa–draining lymph nodes leads to rapid release of cytotoxic CD8+ T cells lacking a gut-homing phenotype
J Barreto de Albuquerque, LM Altenburger, J Abe… - Science …, 2022 - science.org
The gastrointestinal (GI) tract constitutes an essential barrier against ingested microbes,
including potential pathogens. Although immune reactions are well studied in the lower GI …
including potential pathogens. Although immune reactions are well studied in the lower GI …
[HTML][HTML] Segmented filamentous bacteria induce divergent populations of antigen-specific CD4 T cells in the small intestine
CD4 T cells differentiate into RORγt/IL-17A-expressing cells in the small intestine following
colonization by segmented filamentous bacteria (SFB). However, it remains unclear whether …
colonization by segmented filamentous bacteria (SFB). However, it remains unclear whether …
[HTML][HTML] CD4 T cells are required for both development and maintenance of disease in a new mouse model of reversible colitis
J Brasseit, E Althaus-Steiner, M Faderl, N Dickgreber… - Mucosal …, 2016 - Elsevier
Current therapies to treat inflammatory bowel diseases have limited efficacy, significant side
effects, and often wane over time. Little is known about the cellular and molecular …
effects, and often wane over time. Little is known about the cellular and molecular …
The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals
DR Withers, E Jaensson, F Gaspal… - The Journal of …, 2009 - journals.aai.org
Although CD4+ memory T cells reside within secondary lymphoid tissue, the major reservoir
of these cells is in the lamina propria of the intestine. In this study, we demonstrate that, in …
of these cells is in the lamina propria of the intestine. In this study, we demonstrate that, in …
Development of TCRαβ CD8αα Intestinal Intraepithelial Lymphocytes Is Promoted by Interleukin-15-Producing Epithelial Cells Constitutively Stimulated by Gram …
M Kaneko, T Mizunuma, H Takimoto… - Biological and …, 2004 - jstage.jst.go.jp
MATERIALS AND METHODS Mice Female C3H/He and C3H/HeJ mice were obtained from
Japan SLC Inc.(Shizuoka, Japan). BALB/c mice were purchased as breeding pairs from …
Japan SLC Inc.(Shizuoka, Japan). BALB/c mice were purchased as breeding pairs from …
Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues
Differentiation and maintenance of recirculating effector memory CD8 T cells (T EM)
depends on prolonged cognate Ag stimulation. Whether similar pathways of differentiation …
depends on prolonged cognate Ag stimulation. Whether similar pathways of differentiation …