The structural determinants of mibefradil inhibition were analyzed using wild-type and
inactivation-modified Ca V 1.2 (α1C) and Ca V 2.3 (α1E) channels. Mibefradil inhibition of …

The voltage gated calcium channel family is a major target for a range of therapeutic drugs.
Mibefradil (Ro 40–5967) belongs to a new chemical class of these molecules which differs …

To study the molecular pharmacology of low-voltage–activated calcium channels in
biophysical detail, human medullary thyroid carcinoma (hMTC) cells were investigated using …

Mibefradil is a novel Ca2+ antagonist which blocks both high‐voltage activated and low
voltage‐activated Ca2+ channels. Although L‐type Ca2+ channel block was demonstrated …

Mibefradil is a T-type Ca2+ channel antagonist with reported cross-reactivity with other
classes of ion channels, including K+, Cl-, and Na+ channels. Using whole-cell voltage …

Mechanism of voltage- and use-dependent block of class A Ca2+ channels by mibefradil Page
1 Mechanism of voltage- and use-dependent block of class A Ca2+ channels by mibefradil 1S …

Mibefradil is a Ca2+ channel antagonist that inhibits both T-type and high-voltage-activated
Ca2+ channels. We previously showed that block of high-voltage-activated channels by …

We compared detailed efficacy of efonidipine and nifedipine, dihydropyridine analogues,
and mibefradil using recombinant T-and L-type Ca2+ channels expressed separately in …

ABSTRACT NNC 55‐0396 is a structural analog of mibefradil (Ro 40‐5967) that inhibits
both T‐type and high‐voltage‐activated (HVA) Ca2+ channels with a higher selectivity for T …

Four different types of Ca2 channel cxl subunits, representing the major classes of voltage-
gated Ca2 channels, were mdividually coexpressed along with cs2Th and f32b subunits in …