Metabolic activation of benzo (a) pyrene (BP) to its ultimate carcinogenic form, 7β, 8α-diol-
9α, 10α-benzo (a) pyrene epoxide (BPDE), and the binding of BPDE to DNA are important …

Coke oven workers are exposed to high levels of carcinogenic polycyclic aromatic
hydrocarbons, including benzo [a] pyrene (B [a] P), and are at increased risk of lung cancer …

A highly-sensitive immunoassay utilizing antiserum specific for benzo [a] pyrene covalently
bound to DNA has been employed to probe for adducts in the DNA of animal and human …

Ultrasensitive enzymatic radioimmunoassay (USERIA) was compared to radioimmunoassay
and enzyme-linked immunosorbent assay in determining the amount of benzo (a) pyrene [B …

Benzo [a] pyrene (BP) was bound to DNA by horseradish peroxidase, rat liver microsomes,
and ratliver nuclei in vitro and in mouse skin in vivo. The BP-DNA adducts formed were …

Human bronchus is one target site for the carcinogenic action of tobacco smoke, which
contains chemical carcinogens, including benzo (a) pyrene. Human bronchi were obtained …

Metabolic activation of benzo [α] pyrene (BaP) by cellular enzymes is required for DNA
adduct formation. In vivo DNA adducts might also arise from BaP metabolites supplied via …

Monoclonal antibodies were obtained after fusion of mouse P3× 63 Ag8. 653 myeloma cells
with spleen cells isolated from BALB/cCr mice immunized with either DNA modified by 7β …

The metabolism of benzo (a) pyrene in cultured human colon has been investigated.
Nontumorous colonic tissue was collected at the time of either surgery or “immediate …

Benzo (a) pyrene (BP) and other polycyclic aromatic hydrocarbons (PAH) are ubiquitous
environmental pollutants and are suspected to be carcinogenic in man. The in vivo formation …