Salmonella Typhimurium (S. Typhimurium) is an aggressive zoonotic pathogen that causes
enteritis and diarrhea. Antibiotic therapy is still the primary method at present. However, the …

The opportunistic Gram-negative bacterium Acinetobacter baumannii (AB) is a leading
cause of life-threatening nosocomial pneumonia. Outbreaks of multidrug resistant (MDR)-AB …

Vibrio alginolyticus is a food-borne marine Vibrio that causes gastroenteritis, otitis media,
otitis externa, and septicemia in humans. The pathogenic mechanisms of V. alginolyticus …

The nucleotide-binding domain, leucine-rich repeat containing family caspase recruitment
domain containing 4 (NLRC4) inflammasome can be activated by pathogenic bacteria via …

Citrobacter rodentium is an enteric bacterial pathogen of the mouse intestinal tract that
triggers inflammatory responses resembling those of humans infected with …

Uncontrolled activation of NLRP3 inflammasome initiates a series of human inflammatory
diseases. Targeting NLRP3 inflammasome has attracted considerable attention in …

Vibrio vulnificus and Vibrio cholerae are Gram-negative pathogens that cause serious
infectious disease in humans. The β form of pro–IL-1 is thought to be involved in …

Background Worldwide, more than 125 million people are infected with Shigella each year
and develop shigellosis. In our previous study, we provided evidence that Shigella sonnei …

The macrophage NLRC4 inflammasome drives potent innate immune responses against
Salmonella by eliciting caspase-1-dependent proinflammatory cytokine production (eg …

Tuberculosis (TB) is a zoonotic infectious disease caused by Mycobacterium tuberculosis
(Mtb). Mtb is a typical intracellular parasite, and macrophages are its main host cells. NLRP3 …