Biocompatibility and in vivo evaluation of oligochitosans as cationic modifiers of alginate/Ca microcapsules

M De Castro, G Orive, RM Hernández… - … Research Part A: An …, 2009 - Wiley Online Library
The present article investigates the substitution of poly‐l‐lysine by two different
oligochitosans as membrane‐coating capsule, and its effect on different functionality …

Biocompatible oligochitosans as cationic modifiers of alginate/Ca microcapsules

G Orive, A Bartkowiak, S Lisiecki… - … Research Part B …, 2005 - Wiley Online Library
In the past, it has been proven that by properly adjusting the molecular mass of the
oligochitosan samples, it is possible to optimize the formation of rigid, biocompatible …

Cytotoxicity study of novel water‐soluble chitosan derivatives applied as membrane material of alginate microcapsules

M Sobol, A Bartkowiak, B de Haan… - Journal of Biomedical …, 2013 - Wiley Online Library
The majority of cell encapsulation systems applied so far are based on polyelectrolyte
complexes of alginate and polyvalent metal cations. Although widely used, these systems …

Biocompatibility of alginate–poly-l-lysine microcapsules for cell therapy

G Orive, SK Tam, JL Pedraz, JP Hallé - Biomaterials, 2006 - Elsevier
Cell microencapsulation holds promise for the treatment of many diseases by the continuous
delivery of therapeutic products. The biocompatibility of the microcapsules and their …

Characterization and bioactivity of alginate-quaternized chitosan microcapsules

Y Sun, X Liang, M Zhu, J Zhao, Y Cheng… - … Science, Part A, 2012 - Taylor & Francis
Poly-L-lysine (PLL) can be replaced successfully by quaternized chitosan to prepare
alginate-Ca microcapsules. By changing the compontent of quaternized chitosan mixture …

Alginate–chitosan complex coacervation for cell encapsulation: Effect on mechanical properties and on long‐term viability

L Baruch, M Machluf - Biopolymers: Original research on …, 2006 - Wiley Online Library
The use of chitosan in complexation with alginate appears to be a promising strategy for cell
microencapsulation, due to the biocompatibility of both polymers and the high mechanical …

The cause and influence of sequentially assembling higher and lower deacetylated chitosans on the membrane formation of microcapsule

G Zheng, H Zheng, H Xie, X Liu… - Journal of Biomedical …, 2016 - Wiley Online Library
Alginate‐chitosan (AC) microcapsules with desired strength and biocompatibility are
preferred in cell‐based therapy. Sequential assembly of higher and lower deacetylated …

Effect of poly‐L‐lysine coating on macrophage activation by alginate‐based microcapsules: Assessment using a new in vitro method

S Juste, M Lessard, N Henley… - Journal of Biomedical …, 2005 - Wiley Online Library
The characteristics of the microcapsule surface, which interacts directly with the host
macrophages, may have a role in the biocompatibility of alginate‐poly‐l‐lysine (PLL) …

Effect of surface wettability and charge on protein adsorption onto implantable alginate‐chitosan‐alginate microcapsule surfaces

HG Xie, XX Li, GJ Lv, WY Xie, J Zhu… - … Research Part A: An …, 2010 - Wiley Online Library
Abstract Alginate‐chitosan‐alginate (ACA) microcapsules have been developed as a device
for the transplantation of living cells. However, protein adsorption onto the surface of …

Improving stability and biocompatibility of alginate/chitosan microcapsule by fabricating bi‐functional membrane

G Zheng, X Liu, X Wang, L Chen, H Xie… - Macromolecular …, 2014 - Wiley Online Library
Cell encapsulation technology holds promise for the cell‐based therapy. But poor
mechanical strength and biocompatibility of microcapsule membrane are still obstacles for …