Chemistry and biology of three representative gold (III) compounds as prospective anticancer agents
Aubipyc, ie [(bipydmb-H) Au (OH)][PF6](where bipydmb-H= deprotonated 6-(1, 1-
dimethylbenzyl)-2, 2′-bipyridine), Auoxo6, ie [(bipy2Me) 2Au2 (μ-O) 2][PF6] 2 (where …
dimethylbenzyl)-2, 2′-bipyridine), Auoxo6, ie [(bipy2Me) 2Au2 (μ-O) 2][PF6] 2 (where …
Organogold (III) compounds as experimental anticancer agents: chemical and biological profiles
In the last few years gold (III) complexes have attracted growing attention in the medicinal
chemistry community as candidate anticancer agents. In particular some organogold (III) …
chemistry community as candidate anticancer agents. In particular some organogold (III) …
Dinuclear gold (III) complexes as potential anticancer agents: Structure, reactivity and biological profile of a series of gold (III) oxo-bridged derivatives
C Gabbiani, A Guerri… - The Open …, 2010 - benthamopen.com
Six homologous gold (III) dinuclear oxo-bridged complexes, of the type [(bipy nR) Au (µ-O) 2
Au (bipy nR)][PF 6] 2, bearing variously substituted 2, 2'-bipyridine ligands (bipy nR= 2, 2' …
Au (bipy nR)][PF 6] 2, bearing variously substituted 2, 2'-bipyridine ligands (bipy nR= 2, 2' …
Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs
A Bindoli, MP Rigobello, G Scutari, C Gabbiani… - Coordination Chemistry …, 2009 - Elsevier
The thioredoxin system plays a key role in regulating the overall intracellular redox balance.
It basically comprises the small redox protein thioredoxin (Trx), nicotinamide adenine …
It basically comprises the small redox protein thioredoxin (Trx), nicotinamide adenine …
Molecular mechanisms and proposed targets for selected anticancer gold compounds
Nowadays, gold compounds constitute a family of very promising experimental agents for
cancer treatment. Indeed, several gold (I) and gold (III) compounds were shown to manifest …
cancer treatment. Indeed, several gold (I) and gold (III) compounds were shown to manifest …
Gold (III) complexes with bipyridyl ligands: solution chemistry, cytotoxicity, and DNA binding properties
G Marcon, S Carotti, M Coronnello… - Journal of Medicinal …, 2002 - ACS Publications
Gold (III) compounds generally exhibit significant cytotoxic effects on cancer cell lines and
are of potential interest as antitumor drugs. We report here on the solution chemistry, the …
are of potential interest as antitumor drugs. We report here on the solution chemistry, the …
Proteomics as a tool to disclose the cellular and molecular mechanisms of selected anticancer gold compounds
Gold compounds form an attractive class of cytotoxic metal compounds of potential
application as anticancer agents. Notably, the mode of action of cytotoxic gold compounds …
application as anticancer agents. Notably, the mode of action of cytotoxic gold compounds …
Mechanistic studies on two dinuclear organogold(iii) compounds showing appreciable antiproliferative properties and a high redox stability
Two dinuclear oxo-bridged organogold (iii) compounds, namely [(N, N, C) 2Au2 (μ-O)][PF6]
2 (with N, N, CH= 6-(1-methylbenzyl)-2, 2′-bipyridine, Au22O1; or 6-(1, 1-dimethylbenzyl) …
2 (with N, N, CH= 6-(1-methylbenzyl)-2, 2′-bipyridine, Au22O1; or 6-(1, 1-dimethylbenzyl) …
Structural and solution chemistry, antiproliferative effects, and DNA and protein binding properties of a series of dinuclear gold (III) compounds with bipyridyl ligands
A Casini, MA Cinellu, G Minghetti… - Journal of Medicinal …, 2006 - ACS Publications
A series of six dinuclear gold (III) oxo complexes with bipyridyl ligands, of general formula
[Au2 (N, N) 2 (μ-O) 2][PF6] 2 (Auoxo1− Auoxo6)[where N, N= 2, 2 '-bipyridine (1), 4, 4 '-di-tert …
[Au2 (N, N) 2 (μ-O) 2][PF6] 2 (Auoxo1− Auoxo6)[where N, N= 2, 2 '-bipyridine (1), 4, 4 '-di-tert …
Exploring the biochemical mechanisms of cytotoxic gold compounds: a proteomic study
We have recently shown that a group of structurally diverse gold compounds are highly
cytotoxic toward a panel of 36 human tumor cell lines through a variety of biochemical …
cytotoxic toward a panel of 36 human tumor cell lines through a variety of biochemical …