Ischemic dose-response in the spinal cord: both immediate and delayed paraplegia

PD Smith, F Puskas, X Meng, D Cho… - Journal of Surgical …, 2012 - Elsevier
BACKGROUND: Paraplegia remains a significant complication of thoracoabdominal aortic
surgery. The study of this spinal cord ischemia and reperfusion injury (SCIR) has been …

Spinal cord ischemic injury: Development of a new model in the rat

GK Kanellopoulos, H Kato, CY Hsu, NT Kouchoukos - Stroke, 1997 - Am Heart Assoc
Background and Purpose Spinal cord ischemic injury (SCII) with resulting paralysis is a
major cause of morbidity after operations on the thoracic aorta. Since the vascular supply to …

Spinal cord ischemia: development of a model in the mouse

L Lang-Lazdunski, K Matsushita, L Hirt, C Waeber… - Stroke, 2000 - Am Heart Assoc
Background and Purpose—Spinal cord ischemia with resulting paraplegia is a devastating
complication of thoracoabdominal aortic surgery. Experimental models of spinal cord …

Ischemia and reperfusion injury of the spinal cord: experimental strategies to examine postischemic paraplegia

F Simon, A Oberhuber - Neural Regeneration Research, 2016 - journals.lww.com
Thoracoabdominal aortic replacement, necessary in case of injuries, aneurysms and
dissections, shows a high complication rate as a consequence of the perioperative …

[HTML][HTML] Reproducible motor deficit following aortic occlusion in a rat model of spinal cord ischemia

JY Hwang, HM Sohn, JH Kim, S Park… - Journal of …, 2017 - pmc.ncbi.nlm.nih.gov
Spinal cord ischemia is a fatal complication following thoracoabdominal aortic aneurysm
surgery. Researchers can investigate the strategies for preventing and treating this …

[HTML][HTML] Reproducable paraplegia by thoracic aortic occlusion in a murine model of spinal cord ischemia-reperfusion

MT Bell, TB Reece, PD Smith, J Mares… - Journal of …, 2014 - pmc.ncbi.nlm.nih.gov
Background Lower extremity paralysis continues to complicate aortic interventions. The lack
of understanding of the underlying pathology has hindered advancements to decrease the …

Evolution of spinal cord injury in a porcine model of prolonged aortic occlusion

JC Papakostas, MI Matsagas, IK Toumpoulis… - Journal of Surgical …, 2006 - Elsevier
BACKGROUND: Spinal cord injury and subsequent paraplegia remains an unpredictable
and devastating complication of thoracoabdominal aortic surgery. The aim of this study was …

Development of a simplified spinal cord ischemia model in mice

Z Wang, W Yang, GW Britz, FW Lombard… - Journal of neuroscience …, 2010 - Elsevier
Use of genetically manipulated mice facilitates understanding pathological mechanisms in
many diseases and contributes to therapy development. However, there is no practical and …

A mouse model of ischemic spinal cord injury with delayed paralysis caused by aortic cross-clamping

H Awad, DP Ankeny, Z Guan, P Wei… - The Journal of the …, 2010 - pubs.asahq.org
Background Spinal cord ischemia and paralysis are devastating perioperative complications
that can accompany open or endovascular repair surgery for aortic aneurysms. Here, we …

Clinical indicators of paraplegia underplay universal spinal cord neuronal injury from transient aortic occlusion

MT Bell, F Puskas, DT Bennett, JC Cleveland Jr… - Brain research, 2015 - Elsevier
Paraplegia following complex aortic intervention relies on crude evaluation of lower
extremity strength such as whether the patient can lift their legs or flex the ankle. Little …