The androgen signaling axis has been the main therapeutic target in the management of
advanced prostate cancer for several decades. Over the past years, significant advances …

Owing to the development of multiple novel therapies, there has been major progress in the
treatment of advanced prostate cancer over the last two decades; however, the disease …

Highlights•Androgen receptor (AR) signaling is a critical driver of prostate cancer cell
proliferation and survival.•Alterations in AR and peripheral production of androgens promote …

Androgens play a critical role in the progression of castration-resistant prostate cancer
through androgen receptor (AR)-regulated signaling pathways. Progress has been made in …

Simple Summary Prostate cancer progression is mainly driven by the androgen receptor
(AR) signaling pathway and its inhibition has been the cornerstone in the treatment of …

Androgen receptor (AR) signaling is a critical pathway for prostate cancer cells, and
androgen-deprivation therapy (ADT) remains the principal treatment for patients with locally …

The discovery of androgen dependence in prostate cancer in 1941 by Huggins and
colleagues has remained the backbone for the treatment of this disease. However, although …

Androgen deprivation therapy targeting the androgens/androgen receptor (AR) signaling
continues to be the mainstay treatment of advanced-stage prostate cancer. The use of …

Introduction The gold standard of medical therapy for advanced prostate cancer is based on
the use of androgen-receptor inhibitors and taxane-based chemotherapy. Several new …

In the last decade, treatment for castration-resistant prostate cancer has changed markedly,
impacting symptom control and longevity for patients. However, a large proportion of cases …