Arachidonic acid is distributed throughout the lipid bilayer of mammalian cells and normally
is esterified to phospholipid. Most arachidonic acid comes directly from the diet or through …

Carcinoma of the colon and/or rectum represents the second most common gastrointestinal
malignancy worldwide. Despite this prevalence, current therapeutic regimens remain largely …

Cancer is predicted to become the leading cause of death–surpassing heart disease–by the
end of this decade. Colorectal cancer is a major health concern, with more than 1,000,000 …

The limited success of current treatments for most advanced common malignancies
highlights the importance of cancer prevention. Clinical trials on cyclooxygenase (COX) …

Colorectal cancer (CRC) leads to approximately 550,000 annual deaths worldwide and is
thus a major public health concern [1]. Once an individual is diagnosed with CRC, the …

Cyclooxygenase (COX) enzyme-dependent arachidonic acid metabolites occupy key
positions in important physiologic processes such as immunity, reproduction, and vascular …

Chemoprevention of colorectal cancer is a promising science that has particular importance
due to the limited success of current treatments for most advanced common malignancies …

Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …

Use of nonsteroidal anti‐inflammatory drugs such as aspirin, which are known to inhibit
cyclooxygenase activity, reduces the relative risk of colorectal cancer in humans by 40–50 …

Risk factors for colorectal cancer have been identified, and significant advances have been
made in understanding the process of colorectal carcinogenesis. The transition from normal …