Modulation of regulatory T cell (Treg) suppression has important implications for vaccine
development, the effectiveness of tumor surveillance, and the emergence of autoimmunity …

Alternatively activated M2 macrophages play an important role in maintenance of tissue
homeostasis by scavenging dead cells, cell debris and lipoprotein aggregates via …

In order to limit the adverse effects of excessive inflammation, anti-inflammatory responses
are stimulated at an early stage of an infection, but during sepsis these can lead to …

Obesity and resistance to insulin are closely associated with the development of low-grade
inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however, its …

Patients who survive sepsis can develop long-term immune dysfunction, with expansion of
the regulatory T (Treg) cell population. However, how Treg cells proliferate in these patients …

Innate immune responses are regulated in the intestine to prevent excessive inflammation.
Here we show that a subset of mouse colonic macrophages constitutively produce the anti …

During wound injury, efferocytosis fills the macrophage with a metabolite load nearly equal
to the phagocyte itself. A timely question pertains to how metabolic phagocytic signaling …

Activation of macrophages and dendritic cells (DCs) by pro-inflammatory stimuli causes
them to undergo a metabolic switch towards glycolysis and away from oxidative …

Aging impairs the integrated immunometabolic responses, which have evolved to maintain
core body temperature in homeotherms to survive cold stress, infections, and dietary …

Mer tyrosine kinase (MerTK) is a major macrophage apoptotic cell (AC) receptor. Its
functional impairment promotes autoimmunity and atherosclerosis, whereas overexpression …