Transcriptomic profiles underlying functional brain networks at different stages of Alzheimer's disease: Genetics/genetic factors of Alzheimer's disease

M Yu, K Nho, SL Risacher, EJ Chumin… - Alzheimer's & …, 2020 - Wiley Online Library
Background Specific functional network connectivity patterns have been shown at different
stages along the Alzheimer's disease (AD) continuum, but the contribution of regional gene …

Gene co-expression changes underlying the functional connectomic alterations in Alzheimer's disease

B He, P Gorijala, L Xie, S Cao, J Yan - BMC Medical Genomics, 2022 - Springer
Background There is growing evidence indicating that a number of functional connectivity
networks are disrupted at each stage of the full clinical Alzheimer's disease spectrum. Such …

Morphological connectivity differences in Alzheimer's disease correlate with gene transcription and cell‐type

H Yu, Y Ding, Y Wei, M Dyrba, D Wang… - Human brain …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is one of the most prevalent forms of dementia in older individuals.
Convergent evidence suggests structural connectome abnormalities in specific brain …

Relating global and local connectome changes to dementia and targeted gene expression in Alzheimer's disease

SSM Elsheikh, ER Chimusa… - Frontiers in human …, 2021 - frontiersin.org
Networks are present in many aspects of our lives, and networks in neuroscience have
recently gained much attention leading to novel representations of brain connectivity. The …

Subtypes of functional brain connectivity as early markers of neurodegeneration in Alzheimer's disease

P Orban, A Tam, S Urchs, M Savard, C Madjar… - BioRxiv, 2017 - biorxiv.org
Highlights Reliable functional brain network subtypes accompany cognitive impairment in
AD Symptom-related subtypes exist in the default-mode, limbic and salience networks A …

Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles

J Chung, N Sahelijo, T Maruyama, J Hu… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Alzheimer's disease (AD) is heterogeneous, both clinically and
neuropathologically. We investigated whether polygenic risk scores (PRSs) integrated with …

Functional connectivity in autosomal dominant and late-onset Alzheimer disease

JB Thomas, MR Brier, RJ Bateman, AZ Snyder… - JAMA …, 2014 - jamanetwork.com
Importance Autosomal dominant Alzheimer disease (ADAD) is caused by rare genetic
mutations in 3 specific genes in contrast to late-onset Alzheimer disease (LOAD), which has …

Differential network analyses of Alzheimer's disease identify early events in Alzheimer's disease pathology

J Xia, DM Rocke, G Perry, M Ray - International Journal of …, 2014 - Wiley Online Library
In late‐onset Alzheimer's disease (AD), multiple brain regions are not affected
simultaneously. Comparing the gene expression of the affected regions to identify the …

Brain transcriptome wide association study (TWAS) implicates 8 genes across 6 loci in Alzheimer's disease: Genetics: Genetics and omics of AD I

J Gockley, KS Montgomery, WL Poehlman… - Alzheimer's & …, 2020 - Wiley Online Library
Background Alzheimer's disease (AD), an incurable neurodegenerative disease, currently
affects 1.75% of the United States population, with projected growth to 3.46% by 2050 …

Exploratory correlation of the human structural connectome with non‐MRI variables in Alzheimer's disease

I Aganj, J Mora, A Frau‐Pascual… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Discovery of the associations between brain structural connectivity and clinical
and demographic variables can help to better understand the vulnerability and resilience of …