Transcriptomic profiles underlying functional brain networks at different stages of Alzheimer's disease: Genetics/genetic factors of Alzheimer's disease
Background Specific functional network connectivity patterns have been shown at different
stages along the Alzheimer's disease (AD) continuum, but the contribution of regional gene …
stages along the Alzheimer's disease (AD) continuum, but the contribution of regional gene …
Gene co-expression changes underlying the functional connectomic alterations in Alzheimer's disease
Background There is growing evidence indicating that a number of functional connectivity
networks are disrupted at each stage of the full clinical Alzheimer's disease spectrum. Such …
networks are disrupted at each stage of the full clinical Alzheimer's disease spectrum. Such …
Morphological connectivity differences in Alzheimer's disease correlate with gene transcription and cell‐type
Alzheimer's disease (AD) is one of the most prevalent forms of dementia in older individuals.
Convergent evidence suggests structural connectome abnormalities in specific brain …
Convergent evidence suggests structural connectome abnormalities in specific brain …
Relating global and local connectome changes to dementia and targeted gene expression in Alzheimer's disease
SSM Elsheikh, ER Chimusa… - Frontiers in human …, 2021 - frontiersin.org
Networks are present in many aspects of our lives, and networks in neuroscience have
recently gained much attention leading to novel representations of brain connectivity. The …
recently gained much attention leading to novel representations of brain connectivity. The …
Subtypes of functional brain connectivity as early markers of neurodegeneration in Alzheimer's disease
Highlights Reliable functional brain network subtypes accompany cognitive impairment in
AD Symptom-related subtypes exist in the default-mode, limbic and salience networks A …
AD Symptom-related subtypes exist in the default-mode, limbic and salience networks A …
Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles
Introduction Alzheimer's disease (AD) is heterogeneous, both clinically and
neuropathologically. We investigated whether polygenic risk scores (PRSs) integrated with …
neuropathologically. We investigated whether polygenic risk scores (PRSs) integrated with …
Functional connectivity in autosomal dominant and late-onset Alzheimer disease
Importance Autosomal dominant Alzheimer disease (ADAD) is caused by rare genetic
mutations in 3 specific genes in contrast to late-onset Alzheimer disease (LOAD), which has …
mutations in 3 specific genes in contrast to late-onset Alzheimer disease (LOAD), which has …
Differential network analyses of Alzheimer's disease identify early events in Alzheimer's disease pathology
In late‐onset Alzheimer's disease (AD), multiple brain regions are not affected
simultaneously. Comparing the gene expression of the affected regions to identify the …
simultaneously. Comparing the gene expression of the affected regions to identify the …
Brain transcriptome wide association study (TWAS) implicates 8 genes across 6 loci in Alzheimer's disease: Genetics: Genetics and omics of AD I
J Gockley, KS Montgomery, WL Poehlman… - Alzheimer's & …, 2020 - Wiley Online Library
Background Alzheimer's disease (AD), an incurable neurodegenerative disease, currently
affects 1.75% of the United States population, with projected growth to 3.46% by 2050 …
affects 1.75% of the United States population, with projected growth to 3.46% by 2050 …
Exploratory correlation of the human structural connectome with non‐MRI variables in Alzheimer's disease
I Aganj, J Mora, A Frau‐Pascual… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Discovery of the associations between brain structural connectivity and clinical
and demographic variables can help to better understand the vulnerability and resilience of …
and demographic variables can help to better understand the vulnerability and resilience of …
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